Signal peptide(a) |
N |
Secretome P(b) |
0.667 |
Function |
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). . |
GO - Molecular function |
- carboxylic acid binding : ISO:MGI
- L-aspartate : IDA:MGI
- L-cysteine : ISS:UniProtKB
- phosphatidylserine decarboxylase activity : IDA:MGI
- pyridoxal phosphate binding : IEA:InterPro
|
GO - Biological process |
- 2-oxoglutarate metabolic process : ISS:UniProtKB
- aspartate biosynthetic process : IDA:MGI
- aspartate catabolic process : ISO:MGI
- aspartate metabolic process : ISS:UniProtKB
- cellular response to insulin stimulus : IEA:Ensembl
- cellular response to mechanical stimulus : ISO:MGI
- dicarboxylic acid metabolic process : ISO:MGI
- fatty acid homeostasis : IDA:MGI
- glutamate catabolic process to 2-oxoglutarate : IDA:MGI
- glutamate catabolic process to aspartate : IDA:MGI
- glutamate metabolic process : ISS:UniProtKB
- glycerol biosynthetic process : IDA:MGI
- negative regulation of collagen biosynthetic process : ISO:MGI
- negative regulation of cytosolic calcium ion concentration : ISO:MGI
- negative regulation of mitochondrial depolarization : ISO:MGI
- Notch signaling pathway : IDA:MGI
- oxaloacetate metabolic process : IDA:MGI
- positive regulation of transforming growth factor beta receptor signaling pathway : ISO:MGI
- response to cadmium ion : IEA:Ensembl
- response to carbohydrate : IEA:Ensembl
- response to glucocorticoid : IEA:Ensembl
- response to immobilization stress : IEA:Ensembl
- response to transition metal nanoparticle : ISO:MGI
- transdifferentiation : ISO:MGI
|