Elongation factor 2 (P05197)

Uniprot ID P05197
Protein Name Elongation factor 2
Gene Name Eef2
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
GO - Molecular function
  • 5S rRNA binding : IDA:RGD
  • actin filament binding : IDA:RGD
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : ISO:RGD
  • p53 binding : IPI:RGD
  • protein kinase binding : ISO:RGD
  • ribosome binding : IDA:RGD
  • RNA binding : IDA:RGD
  • translation elongation factor activity : IBA:GO_Central
GO - Biological process
  • aging : IEP:RGD
  • cellular response to brain-derived neurotrophic factor stimulus : IEP:RGD
  • glial cell proliferation : IEP:RGD
  • hematopoietic progenitor cell differentiation : ISO:RGD
  • positive regulation of cytoplasmic translation : IMP:RGD
  • positive regulation of translation : IDA:RGD
  • response to drug : IEP:RGD
  • response to endoplasmic reticulum stress : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to ethanol : IEP:RGD
  • response to folic acid : IEP:RGD
  • response to hydrogen peroxide : IEP:RGD
  • response to ischemia : IEP:RGD
  • skeletal muscle cell differentiation : IEP:RGD
  • skeletal muscle contraction : IEP:RGD
  • translational elongation : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.