Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
GO - Molecular function |
- 5S rRNA binding : IDA:RGD
- actin filament binding : IDA:RGD
- GTP binding : IEA:UniProtKB-KW
- GTPase activity : ISO:RGD
- p53 binding : IPI:RGD
- protein kinase binding : ISO:RGD
- ribosome binding : IDA:RGD
- RNA binding : IDA:RGD
- translation elongation factor activity : IBA:GO_Central
|
GO - Biological process |
- aging : IEP:RGD
- cellular response to brain-derived neurotrophic factor stimulus : IEP:RGD
- glial cell proliferation : IEP:RGD
- hematopoietic progenitor cell differentiation : ISO:RGD
- positive regulation of cytoplasmic translation : IMP:RGD
- positive regulation of translation : IDA:RGD
- response to drug : IEP:RGD
- response to endoplasmic reticulum stress : IEP:RGD
- response to estradiol : IEP:RGD
- response to ethanol : IEP:RGD
- response to folic acid : IEP:RGD
- response to hydrogen peroxide : IEP:RGD
- response to ischemia : IEP:RGD
- skeletal muscle cell differentiation : IEP:RGD
- skeletal muscle contraction : IEP:RGD
- translational elongation : ISO:RGD
|