ADP/ATP translocase 2 (P05141)

Uniprot ID P05141
Protein Name ADP/ATP translocase 2
Gene Name SLC25A5
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.035
Function Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. .
GO - Molecular function
  • adenine transmembrane transporter activity : TAS:Reactome
  • ATP : IBA:GO_Central
  • RNA binding : HDA:UniProtKB
  • ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
GO - Biological process
  • cellular response to leukemia inhibitory factor : IEA:Ensembl
  • chromosome segregation : IEA:UniProtKB-KW
  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway : IMP:UniProtKB
  • positive regulation of cell proliferation : IMP:UniProtKB
  • regulation of insulin secretion : TAS:Reactome
  • viral process : IEA:UniProtKB-KW
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.