Plasminogen activator inhibitor 1 (P05121)

Uniprot ID P05121
Protein Name Plasminogen activator inhibitor 1
Gene Name SERPINE1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.59
Function Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:8481516, PubMed:9207454, PubMed:17912461). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). .
GO - Molecular function
  • protease binding : IPI:UniProtKB
  • serine-type endopeptidase inhibitor activity : IDA:BHF-UCL
  • signaling receptor binding : IPI:BHF-UCL
GO - Biological process
  • angiogenesis : IEP:UniProtKB
  • cellular response to calcium ion : HEP:ARUK-UCL
  • cellular response to lipopolysaccharide : IMP:BHF-UCL
  • chronological cell aging : IEP:BHF-UCL
  • circadian rhythm : TAS:Reactome
  • defense response to Gram-negative bacterium : IGI:BHF-UCL
  • dentinogenesis : IDA:UniProtKB
  • extracellular matrix organization : TAS:Reactome
  • fibrinolysis : TAS:Reactome
  • negative regulation of blood coagulation : IC:BHF-UCL
  • negative regulation of cell adhesion mediated by integrin : IDA:BHF-UCL
  • negative regulation of cell migration : IDA:BHF-UCL
  • negative regulation of endopeptidase activity : IDA:BHF-UCL
  • negative regulation of endothelial cell apoptotic process : IMP:BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : IMP:BHF-UCL
  • negative regulation of fibrinolysis : IDA:BHF-UCL
  • negative regulation of plasminogen activation : IDA:BHF-UCL
  • negative regulation of smooth muscle cell migration : IDA:BHF-UCL
  • negative regulation of smooth muscle cell-matrix adhesion : IDA:BHF-UCL
  • negative regulation of vascular wound healing : IGI:BHF-UCL
  • negative regulation of wound healing : IC:BHF-UCL
  • platelet degranulation : TAS:Reactome
  • positive regulation of angiogenesis : IMP:BHF-UCL
  • positive regulation of blood coagulation : IMP:BHF-UCL
  • positive regulation of inflammatory response : IGI:BHF-UCL
  • positive regulation of interleukin-8 production : IMP:BHF-UCL
  • positive regulation of leukotriene production involved in inflammatory response : IMP:BHF-UCL
  • positive regulation of monocyte chemotaxis : IMP:BHF-UCL
  • positive regulation of odontoblast differentiation : IDA:UniProtKB
  • positive regulation of receptor-mediated endocytosis : IDA:BHF-UCL
  • positive regulation of transcription by RNA polymerase II : TAS:Reactome
  • regulation of signaling receptor activity : IDA:BHF-UCL
  • replicative senescence : IMP:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.