| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (By similarity). . |
| GO - Molecular function |
- chromatin binding : ISS:UniProtKB
- damaged DNA binding : ISS:UniProtKB
- dinucleotide insertion or deletion binding : ISO:RGD
- DNA polymerase binding : ISO:RGD
- DNA polymerase processivity factor activity : IBA:GO_Central
- enzyme binding : ISO:RGD
- estrogen receptor binding : IPI:RGD
- histone acetyltransferase binding : ISO:RGD
- identical protein binding : ISO:RGD
- MutLalpha complex binding : ISO:RGD
- protein C-terminus binding : IEA:Ensembl
- purine-specific mismatch base pair DNA N-glycosylase activity : ISO:RGD
- receptor tyrosine kinase binding : ISO:RGD
- transcription factor binding : ISO:RGD
|
| GO - Biological process |
- base-excision repair, gap-filling : ISO:RGD
- cellular response to hydrogen peroxide : IEP:RGD
- cellular response to UV : IEP:RGD
- cellular response to xenobiotic stimulus : ISO:RGD
- epithelial cell differentiation : ISO:RGD
- estrous cycle : IEP:RGD
- heart development : IEP:RGD
- leading strand elongation : IBA:GO_Central
- liver regeneration : IEP:RGD
- mismatch repair : ISO:RGD
- mitotic telomere maintenance via semi-conservative replication : ISO:RGD
- negative regulation of transcription by RNA polymerase II : ISO:RGD
- positive regulation of deoxyribonuclease activity : ISS:UniProtKB
- positive regulation of DNA repair : ISS:UniProtKB
- positive regulation of DNA replication : ISS:UniProtKB
- positive regulation of DNA-directed DNA polymerase activity : IEA:Ensembl
- replication fork processing : ISO:RGD
- response to cadmium ion : IEP:RGD
- response to dexamethasone : IEP:RGD
- response to estradiol : IEP:RGD
- response to L-glutamate : IEP:RGD
- response to lipid : IDA:RGD
- response to oxidative stress : IEP:RGD
- translesion synthesis : ISS:UniProtKB
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