Fibronectin (P04937)

Uniprot ID	P04937
Protein Name	Fibronectin
Gene Name	Fn1
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). .Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling (By similarity). {ECO:0000250}.
GO - Molecular function	chaperone binding : ISO:RGD disordered domain specific binding : ISO:RGD enzyme binding : ISO:RGD extracellular matrix structural constituent : TAS:RGD heparin binding : IEA:UniProtKB-KW identical protein binding : ISO:RGD integrin binding : ISO:RGD mercury ion binding : IDA:RGD peptidase activator activity : ISO:RGD protease binding : IPI:RGD protein C-terminus binding : ISO:RGD proteoglycan binding : ISO:RGD signaling receptor binding : ISO:RGD
GO - Biological process	acute-phase response : IEA:UniProtKB-KW angiogenesis : IEA:UniProtKB-KW calcium-independent cell-matrix adhesion : ISO:RGD cell activation : IMP:RGD cell adhesion : ISO:RGD cell-matrix adhesion : IMP:RGD cell-substrate junction assembly : ISO:RGD cellular response to amyloid-beta : IEP:RGD cellular response to angiotensin : IEP:RGD cellular response to BMP stimulus : IEP:RGD cellular response to glucose stimulus : IEP:RGD cellular response to interleukin-1 : IMP:RGD cellular response to lipopolysaccharide : IEP:RGD cellular response to mercury ion : IDA:RGD cellular response to platelet-derived growth factor stimulus : IEP:RGD cellular response to prostaglandin E stimulus : IEP:RGD cellular response to transforming growth factor beta stimulus : IEP:RGD cellular response to vascular endothelial growth factor stimulus : IEP:RGD endodermal cell differentiation : ISO:RGD extracellular matrix organization : IMP:RGD glial cell migration : IDA:RGD integrin activation : ISO:RGD interaction with symbiont : ISO:RGD negative regulation of apoptotic process : IMP:RGD negative regulation of transforming growth factor-beta secretion : ISO:RGD neural crest cell migration involved in autonomic nervous system development : ISO:RGD ossification : TAS:RGD peptide cross-linking : ISO:RGD positive regulation of axon extension : ISO:RGD positive regulation of cell migration : IMP:RGD positive regulation of cell population proliferation : ISO:RGD positive regulation of chemotaxis : IDA:RGD positive regulation of fibroblast proliferation : ISO:RGD positive regulation of gene expression : ISO:RGD positive regulation of substrate-dependent cell migration, cell attachment to substrate : ISO:RGD regulation of cell shape : IEA:UniProtKB-KW regulation of ERK1 and ERK2 cascade : ISO:RGD regulation of protein phosphorylation : ISO:RGD response to activity : IEP:RGD response to drug : IEP:RGD response to glucocorticoid : IEP:RGD response to iron ion : IEP:RGD response to ischemia : IEP:RGD response to ozone : IEP:RGD response to wounding : IEP:RGD substrate adhesion-dependent cell spreading : ISO:RGD symbiotic process mediated by secreted substance : ISO:RGD wound healing : ISO:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}