Interleukin-3 (P04823)

Uniprot ID P04823
Protein Name Interleukin-3
Gene Name Il3
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.
GO - Molecular function
  • cytokine activity : IDA:RGD
  • growth factor activity : ISO:RGD
  • interleukin-3 receptor binding : IMP:RGD
GO - Biological process
  • activation of Janus kinase activity : ISO:RGD
  • cytokine-mediated signaling pathway : ISO:RGD
  • embryonic hemopoiesis : ISO:RGD
  • extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
  • hemopoiesis : IMP:RGD
  • immune response : IEA:InterPro
  • interleukin-3-mediated signaling pathway : ISO:RGD
  • monocyte differentiation : ISO:RGD
  • myeloid cell apoptotic process : ISO:RGD
  • negative regulation of apoptotic process : ISO:RGD
  • negative regulation of autophagy : ISO:RGD
  • negative regulation of mast cell apoptotic process : ISO:RGD
  • positive regulation of cell population proliferation : IDA:RGD
  • positive regulation of JNK cascade : ISO:RGD
  • positive regulation of mast cell proliferation : ISO:RGD
  • positive regulation of myeloid leukocyte differentiation : ISO:RGD
  • positive regulation of peptidyl-tyrosine phosphorylation : ISS:UniProtKB
  • positive regulation of protein phosphorylation : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : ISO:RGD
  • regulation of cell growth : IMP:RGD
  • regulation of gene expression : ISO:RGD
  • regulation of glycolytic process : ISO:RGD
  • regulation of protein dephosphorylation : ISO:RGD
  • response to hormone : IMP:RGD
  • response to hypoxia : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.