Protein disulfide-isomerase (P04785)

Uniprot ID P04785
Protein Name Protein disulfide-isomerase
Gene Name P4hb
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. .
GO - Molecular function
  • actin binding : IEA:Ensembl
  • enzyme binding : IPI:RGD
  • integrin binding : ISO:RGD
  • peptide disulfide oxidoreductase activity : ISO:RGD
  • procollagen-proline 4-dioxygenase activity : IEA:Ensembl
  • protein disulfide isomerase activity : IMP:RGD
  • protein heterodimerization activity : ISO:RGD
  • protein-containing complex binding : IPI:RGD
GO - Biological process
  • cell redox homeostasis : IEA:InterPro
  • cellular response to hypoxia : ISO:RGD
  • cellular response to interleukin-7 : ISO:RGD
  • peptidyl-proline hydroxylation to 4-hydroxy-L-proline : ISO:RGD
  • positive regulation of substrate adhesion-dependent cell spreading : IEA:Ensembl
  • positive regulation of viral entry into host cell : ISO:RGD
  • protein folding : IBA:GO_Central
  • regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : ISO:RGD
  • response to endoplasmic reticulum stress : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.