Alpha-enolase (P04764)

Uniprot ID P04764
Protein Name Alpha-enolase
Gene Name Eno1
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. .
GO - Molecular function
  • DNA-binding transcription repressor activity, RNA polymerase II-specific : ISO:RGD
  • enzyme binding : IPI:CAFA
  • GTPase binding : ISO:RGD
  • heat shock protein binding : IPI:RGD
  • identical protein binding : IPI:RGD
  • magnesium ion binding : IEA:InterPro
  • phosphopyruvate hydratase activity : IDA:CAFA
  • protein heterodimerization activity : IDA:CAFA
  • protein homodimerization activity : IDA:CAFA
  • protein-containing complex binding : IDA:RGD
  • RNA binding : ISO:RGD
  • RNA polymerase II regulatory region sequence-specific DNA binding : ISO:RGD
GO - Biological process
  • canonical glycolysis : IDA:CAFA
  • cellular response to hypoxia : IDA:CAFA
  • cellular response to interleukin-7 : ISO:RGD
  • ERK1 and ERK2 cascade : IDA:CAFA
  • glycolytic process : IDA:CAFA
  • in utero embryonic development : ISO:RGD
  • negative regulation of cell growth : ISO:RGD
  • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway : ISO:RGD
  • negative regulation of transcription by RNA polymerase II : ISO:RGD
  • negative regulation of transcription, DNA-templated : ISO:RGD
  • positive regulation of ATP biosynthetic process : ISO:RGD
  • positive regulation of binding : ISO:RGD
  • positive regulation of muscle contraction : ISO:RGD
  • positive regulation of plasminogen activation : ISO:RGD
  • protein heterotetramerization : IDA:CAFA
  • response to virus : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.