| Signal peptide(a) |
N |
Secretome P(b) |
0.672 |
| Function |
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. . |
| GO - Molecular function |
- calcium ion binding : IDA:RGD
- calcium-dependent protein binding : IEA:Ensembl
- protein homodimerization activity : IDA:RGD
- RAGE receptor binding : IPI:RGD
- S100 protein binding : IEA:Ensembl
- signaling receptor binding : IPI:RGD
- tau protein binding : ISS:UniProtKB
- zinc ion binding : IDA:RGD
|
| GO - Biological process |
- astrocyte differentiation : IEP:RGD
- cellular response to hypoxia : IEP:RGD
- learning or memory : ISS:UniProtKB
- long-term synaptic potentiation : IEP:RGD
- memory : IEA:Ensembl
- negative regulation of skeletal muscle cell differentiation : IMP:RGD
- positive regulation of apoptotic process : IMP:RGD
- positive regulation of cell proliferation : IMP:RGD
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl
- positive regulation of myelination : IMP:RGD
- positive regulation of synaptic transmission : IMP:RGD
- regulation of cell shape : IMP:RGD
- regulation of neuronal synaptic plasticity : IEA:Ensembl
- response to glucocorticoid : IEP:RGD
- response to methylmercury : IEP:RGD
|