Protein S100-B (P04631)

Uniprot ID P04631
Protein Name Protein S100-B
Gene Name S100b
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b) 0.672
Function Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. .
GO - Molecular function
  • calcium ion binding : IDA:RGD
  • calcium-dependent protein binding : IEA:Ensembl
  • protein homodimerization activity : IDA:RGD
  • RAGE receptor binding : IPI:RGD
  • S100 protein binding : IEA:Ensembl
  • signaling receptor binding : IPI:RGD
  • tau protein binding : ISS:UniProtKB
  • zinc ion binding : IDA:RGD
GO - Biological process
  • astrocyte differentiation : IEP:RGD
  • cellular response to hypoxia : IEP:RGD
  • learning or memory : ISS:UniProtKB
  • long-term synaptic potentiation : IEP:RGD
  • memory : IEA:Ensembl
  • negative regulation of skeletal muscle cell differentiation : IMP:RGD
  • positive regulation of apoptotic process : IMP:RGD
  • positive regulation of cell proliferation : IMP:RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl
  • positive regulation of myelination : IMP:RGD
  • positive regulation of synaptic transmission : IMP:RGD
  • regulation of cell shape : IMP:RGD
  • regulation of neuronal synaptic plasticity : IEA:Ensembl
  • response to glucocorticoid : IEP:RGD
  • response to methylmercury : IEP:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.