Complement factor B (P04186)

Uniprot ID P04186
Protein Name Complement factor B
Gene Name Cfb
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.479
Function Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
GO - Molecular function
  • serine-type endopeptidase activity : IEA:InterPro
GO - Biological process
  • cell proliferation : TAS:MGI
  • complement activation : ISO:MGI
  • complement activation, alternative pathway : IMP:MGI
  • response to thyroid hormone : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.