| Signal peptide(a) |
N |
Secretome P(b) |
0.425 |
| Function |
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). . |
| GO - Molecular function |
- amyloid-beta binding : IDA:ARUK-UCL
- aspartic-type endopeptidase inhibitor activity : ISS:ARUK-UCL
- ATP-dependent protein binding : IEA:Ensembl
- calcium ion binding : IBA:GO_Central
- calcium-dependent protein binding : IBA:GO_Central
- chaperone binding : IEA:Ensembl
- chondroitin sulfate binding : IBA:GO_Central
- copper ion binding : IDA:UniProtKB
- cupric ion binding : IEA:Ensembl
- cuprous ion binding : IMP:CAFA
- glycosaminoglycan binding : ISS:ARUK-UCL
- heparin binding : IBA:GO_Central
- identical protein binding : IMP:CAFA
- ion channel binding : IEA:Ensembl
- lamin binding : IEA:Ensembl
- microtubule binding : IDA:UniProtKB
- protease binding : ISS:ARUK-UCL
- protein-containing complex binding : IPI:ARUK-UCL
- signaling receptor activity : ISS:ARUK-UCL
- tubulin binding : IDA:UniProtKB
- type 5 metabotropic glutamate receptor binding : IPI:ARUK-UCL
|
| GO - Biological process |
- activation of protein kinase activity : IEA:Ensembl
- calcium-mediated signaling using intracellular calcium source : IGI:ARUK-UCL
- cell cycle arrest : IEA:UniProtKB-KW
- cellular copper ion homeostasis : NAS:UniProtKB
- cellular response to amyloid-beta : IGI:ARUK-UCL
- cellular response to copper ion : IDA:MGI
- cellular response to drug : IEA:Ensembl
- dendritic spine maintenance : TAS:ARUK-UCL
- epithelial cell differentiation : IBA:GO_Central
- learning or memory : ISS:ARUK-UCL
- long-term memory : TAS:ARUK-UCL
- modulation of age-related behavioral decline : ISS:ARUK-UCL
- negative regulation of activated T cell proliferation : ISS:BHF-UCL
- negative regulation of amyloid precursor protein catabolic process : ISS:ARUK-UCL
- negative regulation of amyloid-beta formation : ISS:ARUK-UCL
- negative regulation of apoptotic process : IEA:Ensembl
- negative regulation of calcineurin-NFAT signaling cascade : ISS:BHF-UCL
- negative regulation of dendritic spine maintenance : ISS:ARUK-UCL
- negative regulation of DNA-binding transcription factor activity : ISS:BHF-UCL
- negative regulation of interferon-gamma production : ISS:BHF-UCL
- negative regulation of interleukin-17 production : ISS:BHF-UCL
- negative regulation of interleukin-2 production : ISS:BHF-UCL
- negative regulation of long-term synaptic potentiation : IEA:Ensembl
- negative regulation of protein phosphorylation : ISS:BHF-UCL
- negative regulation of protein processing : TAS:ARUK-UCL
- negative regulation of T cell receptor signaling pathway : ISS:BHF-UCL
- neuron projection maintenance : ISS:ARUK-UCL
- Notch signaling pathway : IBA:GO_Central
- positive regulation of neuron apoptotic process : IMP:CAFA
- positive regulation of neuron death : ISS:ARUK-UCL
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:ARUK-UCL
- positive regulation of protein localization to plasma membrane : IEA:Ensembl
- positive regulation of protein targeting to membrane : ISS:ARUK-UCL
- positive regulation of protein tyrosine kinase activity : IGI:ARUK-UCL
- protein destabilization : IMP:CAFA
- protein homooligomerization : IMP:CAFA
- regulation of calcium ion import across plasma membrane : ISS:ARUK-UCL
- regulation of glutamate receptor signaling pathway : ISS:ARUK-UCL
- regulation of intracellular calcium activated chloride channel activity : IGI:ARUK-UCL
- regulation of peptidyl-tyrosine phosphorylation : ISS:ARUK-UCL
- regulation of potassium ion transmembrane transport : IEA:Ensembl
- response to amyloid-beta : ISS:ARUK-UCL
- response to cadmium ion : IEA:Ensembl
- response to oxidative stress : ISS:UniProtKB
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