Keratin, type II cytoskeletal 1 (P04104)

Uniprot ID P04104
Protein Name Keratin, type II cytoskeletal 1
Gene Name Krt1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.141
Function May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity). .
GO - Molecular function
  • carbohydrate binding : ISO:MGI
  • protein heterodimerization activity : ISS:UniProtKB
  • structural constituent of epidermis : ISO:MGI
GO - Biological process
  • complement activation, lectin pathway : ISO:MGI
  • establishment of skin barrier : IMP:MGI
  • negative regulation of inflammatory response : IMP:MGI
  • peptide cross-linking : ISO:MGI
  • protein heterotetramerization : ISS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.