| Signal peptide(a) |
Y |
Secretome P(b) |
0.903 |
| Function |
Met-and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(239-260) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. . |
| GO - Molecular function |
- opioid peptide activity : IEA:UniProtKB-KW
- opioid receptor binding : IBA:GO_Central
|
| GO - Biological process |
- aggressive behavior : ISO:RGD
- aging : IEP:RGD
- behavioral fear response : ISO:RGD
- cellular response to cAMP : IEP:RGD
- cellular response to oxidative stress : IEP:RGD
- cellular response to transforming growth factor beta stimulus : IEP:RGD
- cellular response to virus : IEP:RGD
- cellular response to vitamin D : IEP:RGD
- chemical synaptic transmission : IBA:GO_Central
- general adaptation syndrome, behavioral process : IEP:RGD
- glial cell proliferation : IEP:RGD
- locomotory behavior : ISO:RGD
- locomotory exploration behavior : IMP:RGD
- neuropeptide signaling pathway : IBA:GO_Central
- osteoblast differentiation : IEP:RGD
- positive regulation of behavioral fear response : IMP:RGD
- response to bacterium : ISO:RGD
- response to calcium ion : IEP:RGD
- response to epinephrine : IEP:RGD
- response to estradiol : IEP:RGD
- response to ethanol : IEP:RGD
- response to hypoxia : IEP:RGD
- response to lipopolysaccharide : IEP:RGD
- response to morphine : IEP:RGD
- response to nicotine : IEP:RGD
- response to radiation : IEP:RGD
- response to toxic substance : IEP:RGD
- sensory perception of pain : ISO:RGD
- startle response : ISO:RGD
- synaptic signaling via neuropeptide : IMP:SynGO
|