Platelet-derived growth factor subunit A (P04085)

Uniprot ID	P04085
Protein Name	Platelet-derived growth factor subunit A
Gene Name	PDGFA
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.8
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). .
GO - Molecular function	collagen binding : IDA:MGI growth factor activity : IDA:UniProtKB identical protein binding : IPI:IntAct platelet-derived growth factor binding : IPI:BHF-UCL platelet-derived growth factor receptor binding : IDA:BHF-UCL protein heterodimerization activity : IPI:BHF-UCL protein homodimerization activity : IDA:BHF-UCL
GO - Biological process	actin cytoskeleton organization : ISS:UniProtKB angiogenesis : ISS:UniProtKB animal organ morphogenesis : ISS:UniProtKB cell activation : TAS:BHF-UCL cell projection assembly : ISS:UniProtKB cell-cell signaling : TAS:ProtInc embryonic lung development : ISS:BHF-UCL extracellular matrix organization : TAS:Reactome hair follicle development : ISS:UniProtKB lung alveolus development : ISS:UniProtKB MAPK cascade : TAS:Reactome negative chemotaxis : IDA:BHF-UCL negative regulation of phosphatidylinositol biosynthetic process : IDA:BHF-UCL negative regulation of platelet activation : IDA:BHF-UCL platelet degranulation : TAS:Reactome platelet-derived growth factor receptor signaling pathway : IDA:BHF-UCL positive regulation of cell division : IEA:UniProtKB-KW positive regulation of cell migration : IDA:UniProtKB positive regulation of cell population proliferation : IDA:BHF-UCL positive regulation of ERK1 and ERK2 cascade : IDA:UniProtKB positive regulation of fibroblast proliferation : IDA:BHF-UCL positive regulation of MAP kinase activity : IDA:UniProtKB positive regulation of MAPK cascade : IMP:UniProtKB positive regulation of mesenchymal cell proliferation : ISS:UniProtKB positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway : IDA:UniProtKB positive regulation of phosphatidylinositol 3-kinase signaling : IDA:UniProtKB positive regulation of protein autophosphorylation : IDA:UniProtKB positive regulation of protein kinase B signaling : IDA:UniProtKB regulation of actin cytoskeleton organization : TAS:BHF-UCL regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling : ISS:UniProtKB regulation of peptidyl-tyrosine phosphorylation : ISS:UniProtKB regulation of smooth muscle cell migration : IDA:BHF-UCL response to wounding : IDA:BHF-UCL skin development : ISS:UniProtKB wound healing : TAS:BHF-UCL

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}