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P04080

Cystatin-B (P04080)

Uniprot ID P04080
Protein Name Cystatin-B
Gene Name CSTB
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.634
Function This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.
GO - Molecular function
  • cysteine-type endopeptidase inhibitor activity : IDA:UniProtKB
  • endopeptidase inhibitor activity : TAS:ProtInc
  • protease binding : IPI:BHF-UCL
  • RNA binding : HDA:UniProtKB
GO - Biological process
  • adult locomotory behavior : IEA:Ensembl
  • negative regulation of peptidase activity : IDA:BHF-UCL
  • negative regulation of proteolysis : IDA:UniProtKB
  • neutrophil degranulation : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.