Glial fibrillary acidic protein (P03995)

Uniprot ID P03995
Protein Name Glial fibrillary acidic protein
Gene Name Gfap
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.736
Function GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
GO - Molecular function
  • identical protein binding : ISO:MGI
  • integrin binding : ISO:MGI
  • kinase binding : ISO:MGI
  • structural constituent of cytoskeleton : ISO:MGI
  • structural molecule activity : IMP:MGI
GO - Biological process
  • astrocyte development : IGI:MGI
  • Bergmann glial cell differentiation : IMP:MGI
  • extracellular matrix organization : IMP:MGI
  • intermediate filament organization : IMP:MGI
  • intermediate filament-based process : IMP:MGI
  • long-term synaptic potentiation : IMP:MGI
  • negative regulation of neuron projection development : IMP:MGI
  • neuron projection regeneration : IMP:MGI
  • positive regulation of glial cell proliferation : ISO:MGI
  • positive regulation of Schwann cell proliferation : IMP:MGI
  • regulation of chaperone-mediated autophagy : IMP:ParkinsonsUK-UCL
  • regulation of neurotransmitter uptake : IMP:MGI
  • response to wounding : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.