| Signal peptide(a) |
N |
Secretome P(b) |
0.461 |
| Function |
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:9272950). Plays an important role in purine metabolism and in adenosine homeostasis (PubMed:9272950, PubMed:10720488). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (PubMed:11435465). Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (PubMed:9272950). . |
| GO - Molecular function |
- adenosine deaminase activity : IDA:UniProtKB
- purine nucleoside binding : ISO:MGI
- zinc ion binding : IDA:UniProtKB
|
| GO - Biological process |
- adenosine catabolic process : IDA:UniProtKB
- adenosine metabolic process : ISO:MGI
- aging : IEA:Ensembl
- cell adhesion : IEA:UniProtKB-KW
- dATP catabolic process : IDA:MGI
- deoxyadenosine catabolic process : IDA:MGI
- embryonic digestive tract development : IMP:MGI
- germinal center B cell differentiation : IMP:MGI
- histamine secretion : ISO:MGI
- hypoxanthine biosynthetic process : IMP:MGI
- hypoxanthine salvage : IBA:GO_Central
- in utero embryonic development : IMP:MGI
- inosine biosynthetic process : IDA:UniProtKB
- liver development : IMP:MGI
- lung alveolus development : IMP:MGI
- lung development : IMP:MGI
- negative regulation of adenosine receptor signaling pathway : ISO:MGI
- negative regulation of apoptotic process : IMP:MGI
- negative regulation of circadian sleep/wake cycle, non-REM sleep : ISO:MGI
- negative regulation of inflammatory response : IMP:MGI
- negative regulation of leukocyte migration : IMP:MGI
- negative regulation of mature B cell apoptotic process : IMP:MGI
- negative regulation of mucus secretion : IMP:MGI
- negative regulation of penile erection : IMP:MGI
- negative regulation of thymocyte apoptotic process : IMP:MGI
- Peyer's patch development : IMP:MGI
- placenta development : IMP:MGI
- positive regulation of alpha-beta T cell differentiation : IMP:MGI
- positive regulation of B cell proliferation : IMP:MGI
- positive regulation of calcium-mediated signaling : IMP:MGI
- positive regulation of germinal center formation : IMP:MGI
- positive regulation of heart rate : IMP:MGI
- positive regulation of smooth muscle contraction : IMP:MGI
- positive regulation of T cell activation : IMP:MGI
- positive regulation of T cell differentiation : IMP:MGI
- positive regulation of T cell differentiation in thymus : IMP:MGI
- positive regulation of T cell receptor signaling pathway : IMP:MGI
- purine nucleotide salvage : ISO:MGI
- purine ribonucleoside monophosphate biosynthetic process : IEA:InterPro
- regulation of cell-cell adhesion mediated by integrin : ISO:MGI
- regulation of T cell differentiation : IMP:MGI
- response to hydrogen peroxide : IEA:Ensembl
- response to hypoxia : ISO:MGI
- response to morphine : ISO:MGI
- response to vitamin E : ISO:MGI
- T cell activation : ISO:MGI
- trophectodermal cell differentiation : IMP:MGI
- xanthine biosynthetic process : IMP:MGI
|