Adenosine deaminase (P03958)

Uniprot ID P03958
Protein Name Adenosine deaminase
Gene Name Ada
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.461
Function Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:9272950). Plays an important role in purine metabolism and in adenosine homeostasis (PubMed:9272950, PubMed:10720488). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (PubMed:11435465). Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (PubMed:9272950). .
GO - Molecular function
  • adenosine deaminase activity : IDA:UniProtKB
  • purine nucleoside binding : ISO:MGI
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • adenosine catabolic process : IDA:UniProtKB
  • adenosine metabolic process : ISO:MGI
  • aging : IEA:Ensembl
  • cell adhesion : IEA:UniProtKB-KW
  • dATP catabolic process : IDA:MGI
  • deoxyadenosine catabolic process : IDA:MGI
  • embryonic digestive tract development : IMP:MGI
  • germinal center B cell differentiation : IMP:MGI
  • histamine secretion : ISO:MGI
  • hypoxanthine biosynthetic process : IMP:MGI
  • hypoxanthine salvage : IBA:GO_Central
  • in utero embryonic development : IMP:MGI
  • inosine biosynthetic process : IDA:UniProtKB
  • liver development : IMP:MGI
  • lung alveolus development : IMP:MGI
  • lung development : IMP:MGI
  • negative regulation of adenosine receptor signaling pathway : ISO:MGI
  • negative regulation of apoptotic process : IMP:MGI
  • negative regulation of circadian sleep/wake cycle, non-REM sleep : ISO:MGI
  • negative regulation of inflammatory response : IMP:MGI
  • negative regulation of leukocyte migration : IMP:MGI
  • negative regulation of mature B cell apoptotic process : IMP:MGI
  • negative regulation of mucus secretion : IMP:MGI
  • negative regulation of penile erection : IMP:MGI
  • negative regulation of thymocyte apoptotic process : IMP:MGI
  • Peyer's patch development : IMP:MGI
  • placenta development : IMP:MGI
  • positive regulation of alpha-beta T cell differentiation : IMP:MGI
  • positive regulation of B cell proliferation : IMP:MGI
  • positive regulation of calcium-mediated signaling : IMP:MGI
  • positive regulation of germinal center formation : IMP:MGI
  • positive regulation of heart rate : IMP:MGI
  • positive regulation of smooth muscle contraction : IMP:MGI
  • positive regulation of T cell activation : IMP:MGI
  • positive regulation of T cell differentiation : IMP:MGI
  • positive regulation of T cell differentiation in thymus : IMP:MGI
  • positive regulation of T cell receptor signaling pathway : IMP:MGI
  • purine nucleotide salvage : ISO:MGI
  • purine ribonucleoside monophosphate biosynthetic process : IEA:InterPro
  • regulation of cell-cell adhesion mediated by integrin : ISO:MGI
  • regulation of T cell differentiation : IMP:MGI
  • response to hydrogen peroxide : IEA:Ensembl
  • response to hypoxia : ISO:MGI
  • response to morphine : ISO:MGI
  • response to vitamin E : ISO:MGI
  • T cell activation : ISO:MGI
  • trophectodermal cell differentiation : IMP:MGI
  • xanthine biosynthetic process : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.