| Signal peptide(a) |
Y |
Secretome P(b) |
0.903 |
| Function |
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. . |
| GO - Molecular function |
- actin binding : IDA:UniProtKB
- copper ion binding : IDA:UniProtKB
- DNA binding : IC:UniProtKB
- endonuclease activity : TAS:UniProtKB
- heparin binding : IDA:UniProtKB
- peptide binding : IDA:UniProtKB
- protein homodimerization activity : IDA:UniProtKB
- ribonuclease activity : IDA:UniProtKB
- rRNA binding : TAS:UniProtKB
- signaling receptor binding : IDA:UniProtKB
|
| GO - Biological process |
- actin filament polymerization : ISS:UniProtKB
- activation of phospholipase A2 activity : IMP:UniProtKB
- activation of phospholipase C activity : IMP:UniProtKB
- activation of protein kinase B activity : IMP:UniProtKB
- adherens junction organization : TAS:Reactome
- angiogenesis : IDA:MGI
- antibacterial humoral response : IDA:UniProtKB
- antifungal humoral response : IDA:UniProtKB
- antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
- cell communication : NAS:UniProtKB
- cell migration : IMP:UniProtKB
- defense response to Gram-positive bacterium : IDA:UniProtKB
- diacylglycerol biosynthetic process : IDA:UniProtKB
- homeostatic process : NAS:UniProtKB
- innate immune response : IDA:UniProtKB
- negative regulation of smooth muscle cell proliferation : IDA:UniProtKB
- negative regulation of translation : IEA:UniProtKB-KW
- oocyte maturation : NAS:UniProtKB
- ovarian follicle development : NAS:UniProtKB
- placenta development : NAS:UniProtKB
- positive regulation of endothelial cell proliferation : IDA:UniProtKB
- positive regulation of phosphorylation : IDA:UniProtKB
- positive regulation of protein secretion : IDA:UniProtKB
- response to hormone : IDA:UniProtKB
- response to hypoxia : IDA:UniProtKB
- response to yeast : IDA:UniProtKB
- rRNA transcription : IMP:UniProtKB
|