Metallothionein-1 (P02802)

Uniprot ID P02802
Protein Name Metallothionein-1
Gene Name Mt1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.848
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GO - Molecular function
  • copper ion binding : IDA:MGI
  • metal ion binding : IDA:MGI
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular metal ion homeostasis : IDA:MGI
  • cellular response to chromate : IDA:MGI
  • cellular response to zinc ion : IDA:MGI
  • cellular zinc ion homeostasis : IMP:MGI
  • detoxification of copper ion : IGI:MGI
  • negative regulation of growth : ISS:UniProtKB
  • negative regulation of neuron apoptotic process : IDA:UniProtKB
  • nitric oxide mediated signal transduction : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.