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P02798

Metallothionein-2 (P02798)

Uniprot ID P02798
Protein Name Metallothionein-2
Gene Name Mt2
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (7) Interactions
Signal peptide(a) N Secretome P(b) 0.845
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GO - Molecular function
  • zinc ion binding : ISS:UniProtKB
GO - Biological process
  • cellular response to zinc ion : ISS:UniProtKB
  • cellular zinc ion homeostasis : IMP:MGI
  • detoxification of copper ion : IMP:MGI
  • negative regulation of growth : ISS:UniProtKB
  • nitric oxide mediated signal transduction : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.