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P02795

Metallothionein-2 (P02795)

Uniprot ID P02795
Protein Name Metallothionein-2
Gene Name MT2A
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.863
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
GO - Molecular function
  • drug binding : IDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • cellular copper ion homeostasis : TAS:ProtInc
  • cellular response to drug : IDA:UniProtKB
  • cellular response to erythropoietin : IEP:UniProtKB
  • cellular response to interleukin-3 : IEP:UniProtKB
  • cellular response to zinc ion : IEP:UniProtKB
  • interferon-gamma-mediated signaling pathway : TAS:Reactome
  • negative regulation of growth : ISS:UniProtKB
  • response to metal ion : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.