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P02794

Ferritin heavy chain (P02794)

Uniprot ID P02794
Protein Name Ferritin heavy chain
Gene Name FTH1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.672
Function Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). .
GO - Molecular function
  • ferric iron binding : IBA:GO_Central
  • ferrous iron binding : IBA:GO_Central
  • ferroxidase activity : IBA:GO_Central
  • identical protein binding : IBA:GO_Central
  • iron ion binding : IBA:GO_Central
GO - Biological process
  • cellular iron ion homeostasis : TAS:Reactome
  • immune response : ISS:UniProtKB
  • intracellular sequestering of iron ion : IDA:UniProtKB
  • iron ion transport : IEA:InterPro
  • negative regulation of cell population proliferation : ISS:UniProtKB
  • negative regulation of fibroblast proliferation : IDA:UniProtKB
  • neutrophil degranulation : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.