| Signal peptide(a) |
N |
Secretome P(b) |
0.611 |
| Function |
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). .(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}. |
| GO - Molecular function |
- double-stranded RNA binding : IDA:MGI
- identical protein binding : IPI:IntAct
- protein homodimerization activity : IPI:BHF-UCL
- RNA binding : HDA:UniProtKB
- transferrin receptor activity : IDA:UniProtKB
- transferrin transmembrane transporter activity : IEA:InterPro
- virus receptor activity : IEA:UniProtKB-KW
|
| GO - Biological process |
- cellular iron ion homeostasis : TAS:ProtInc
- cellular response to drug : IDA:MGI
- cellular response to leukemia inhibitory factor : IEA:Ensembl
- iron ion import : IDA:UniProtKB
- membrane organization : TAS:Reactome
- osteoclast differentiation : IEA:Ensembl
- positive regulation of B cell proliferation : IDA:UniProtKB
- positive regulation of bone resorption : IEA:Ensembl
- positive regulation of isotype switching : IDA:UniProtKB
- positive regulation of T cell proliferation : IDA:UniProtKB
- receptor internalization : IDA:UniProtKB
- transferrin transport : IDA:UniProtKB
|