Transferrin receptor protein 1 (P02786)

Uniprot ID P02786
Protein Name Transferrin receptor protein 1
Gene Name TFRC
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.611
Function Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). .(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.
GO - Molecular function
  • double-stranded RNA binding : IDA:MGI
  • identical protein binding : IPI:IntAct
  • protein homodimerization activity : IPI:BHF-UCL
  • RNA binding : HDA:UniProtKB
  • transferrin receptor activity : IDA:UniProtKB
  • transferrin transmembrane transporter activity : IEA:InterPro
  • virus receptor activity : IEA:UniProtKB-KW
GO - Biological process
  • cellular iron ion homeostasis : TAS:ProtInc
  • cellular response to drug : IDA:MGI
  • cellular response to leukemia inhibitory factor : IEA:Ensembl
  • iron ion import : IDA:UniProtKB
  • membrane organization : TAS:Reactome
  • osteoclast differentiation : IEA:Ensembl
  • positive regulation of B cell proliferation : IDA:UniProtKB
  • positive regulation of bone resorption : IEA:Ensembl
  • positive regulation of isotype switching : IDA:UniProtKB
  • positive regulation of T cell proliferation : IDA:UniProtKB
  • receptor internalization : IDA:UniProtKB
  • transferrin transport : IDA:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.