C-X-C motif chemokine 10 (P02778)

Uniprot ID P02778
Protein Name C-X-C motif chemokine 10
Gene Name CXCL10
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.829
Function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). .
GO - Molecular function
  • cAMP-dependent protein kinase regulator activity : TAS:ProtInc
  • chemoattractant activity : IDA:UniProtKB
  • chemokine activity : IDA:UniProtKB
  • CXCR3 chemokine receptor binding : IDA:UniProtKB
  • heparin binding : IMP:UniProtKB
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • adenylate cyclase-activating G protein-coupled receptor signaling pathway : IDA:UniProtKB
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • blood circulation : TAS:ProtInc
  • cell surface receptor signaling pathway : TAS:ProtInc
  • cell-cell signaling : TAS:ProtInc
  • cellular response to heat : IEA:Ensembl
  • cellular response to lipopolysaccharide : IMP:MGI
  • chemokine-mediated signaling pathway : IMP:UniProtKB
  • chemotaxis : IDA:UniProtKB
  • cytokine-mediated signaling pathway : TAS:Reactome
  • defense response to virus : IEA:Ensembl
  • endothelial cell activation : IGI:CACAO
  • G protein-coupled receptor signaling pathway : IMP:UniProtKB
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • killing of cells of other organism : IDA:UniProtKB
  • leukocyte chemotaxis : IBA:GO_Central
  • muscle organ development : TAS:ProtInc
  • negative regulation of angiogenesis : IDA:UniProtKB
  • negative regulation of myoblast differentiation : IEA:Ensembl
  • negative regulation of myoblast fusion : IEA:Ensembl
  • neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of cell population proliferation : TAS:ProtInc
  • positive regulation of monocyte chemotaxis : IDA:CACAO
  • positive regulation of release of sequestered calcium ion into cytosol : IDA:UniProtKB
  • positive regulation of T cell migration : IDA:MGI
  • positive regulation of transcription by RNA polymerase II : TAS:UniProtKB
  • regulation of apoptotic process : IDA:UniProtKB
  • regulation of cell population proliferation : IDA:UniProtKB
  • regulation of endothelial tube morphogenesis : IDA:CACAO
  • regulation of T cell chemotaxis : IDA:CACAO
  • response to auditory stimulus : IEA:Ensembl
  • response to cold : IEA:Ensembl
  • response to gamma radiation : IEA:Ensembl
  • response to vitamin D : IEA:Ensembl
  • signal transduction : TAS:ProtInc
  • T cell chemotaxis : IMP:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.