Serum albumin (P02770)

Uniprot ID P02770
Protein Name Serum albumin
Gene Name Alb
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity). .
GO - Molecular function
  • chaperone binding : ISO:RGD
  • DNA binding : ISS:UniProtKB
  • drug binding : IPI:RGD
  • enterobactin binding : ISS:UniProtKB
  • enzyme binding : IPI:RGD
  • exogenous protein binding : ISO:RGD
  • fatty acid binding : IDA:RGD
  • identical protein binding : ISO:RGD
  • pyridoxal phosphate binding : ISS:UniProtKB
  • toxic substance binding : ISS:UniProtKB
  • zinc ion binding : IDA:RGD
GO - Biological process
  • cellular response to starvation : ISS:UniProtKB
  • maintenance of mitochondrion location : ISS:UniProtKB
  • negative regulation of apoptotic process : ISS:UniProtKB
  • negative regulation of protein oligomerization : ISO:RGD
  • positive regulation of circadian sleep/wake cycle, non-REM sleep : IDA:RGD
  • response to mercury ion : IEP:RGD
  • response to nutrient : IEP:RGD
  • response to organic substance : IEP:RGD
  • response to platinum ion : IEP:RGD
  • vasodilation : NAS:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.