Alpha-2-HS-glycoprotein (P02765)

Uniprot ID P02765
Protein Name Alpha-2-HS-glycoprotein
Gene Name AHSG
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.441
Function Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions.
GO - Molecular function
  • cysteine-type endopeptidase inhibitor activity : IEA:InterPro
  • endopeptidase inhibitor activity : IBA:GO_Central
  • kinase inhibitor activity : NAS:UniProtKB
GO - Biological process
  • acute-phase response : IDA:UniProtKB
  • cellular protein metabolic process : TAS:Reactome
  • negative regulation of biomineral tissue development : IBA:GO_Central
  • negative regulation of bone mineralization : ISS:UniProtKB
  • negative regulation of insulin receptor signaling pathway : NAS:UniProtKB
  • neutrophil degranulation : TAS:Reactome
  • ossification : IEA:Ensembl
  • pinocytosis : NAS:UniProtKB
  • platelet degranulation : TAS:Reactome
  • positive regulation of phagocytosis : IDA:UniProtKB
  • post-translational protein modification : TAS:Reactome
  • regulation of bone mineralization : NAS:UniProtKB
  • regulation of inflammatory response : IMP:UniProtKB
  • skeletal system development : NAS:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.