Fibronectin (P02751)

Uniprot ID	P02751
Protein Name	Fibronectin
Gene Name	FN1
Species	Homo sapiens (Human)

Signal peptide^(a)	N	Secretome P^(b)	0.451
Function	Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
GO - Molecular function	chaperone binding : IPI:CAFA collagen binding : NAS:UniProtKB disordered domain specific binding : IPI:CAFA enzyme binding : IPI:CAFA extracellular matrix structural constituent : HDA:BHF-UCL heparin binding : NAS:UniProtKB identical protein binding : IPI:IntAct integrin binding : IDA:UniProtKB peptidase activator activity : IEA:Ensembl protease binding : IPI:BHF-UCL protein C-terminus binding : IPI:CAFA proteoglycan binding : IDA:MGI signaling receptor binding : IPI:CAFA
GO - Biological process	acute-phase response : IEA:UniProtKB-KW angiogenesis : IEA:UniProtKB-KW calcium-independent cell-matrix adhesion : IEA:Ensembl cell adhesion : NAS:UniProtKB cell-substrate junction assembly : IEA:Ensembl cellular protein metabolic process : TAS:Reactome cytokine-mediated signaling pathway : TAS:Reactome endodermal cell differentiation : IDA:UniProtKB extracellular matrix organization : TAS:Reactome integrin activation : IMP:UniProtKB interaction with symbiont : IDA:CAFA leukocyte migration : TAS:Reactome negative regulation of transforming growth factor-beta secretion : IDA:UniProtKB neural crest cell migration involved in autonomic nervous system development : IDA:MGI peptide cross-linking : IDA:BHF-UCL platelet degranulation : TAS:Reactome positive regulation of axon extension : IEA:Ensembl positive regulation of cell population proliferation : IDA:UniProtKB positive regulation of fibroblast proliferation : IDA:UniProtKB positive regulation of gene expression : IDA:UniProtKB positive regulation of substrate-dependent cell migration, cell attachment to substrate : IDA:UniProtKB post-translational protein modification : TAS:Reactome regulation of cell shape : IEA:UniProtKB-KW regulation of ERK1 and ERK2 cascade : IDA:UniProtKB regulation of protein phosphorylation : IDA:UniProtKB response to wounding : NAS:UniProtKB substrate adhesion-dependent cell spreading : IDA:BHF-UCL symbiotic process mediated by secreted substance : IDA:CAFA wound healing : IEA:Ensembl

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}