| Signal peptide(a) |
Y |
Secretome P(b) |
0.846 |
| Function |
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues. . |
| GO - Molecular function |
- amyloid-beta binding : IDA:UniProtKB
- antioxidant activity : IDA:BHF-UCL
- cholesterol binding : IBA:GO_Central
- cholesterol transporter activity : IBA:GO_Central
- heparin binding : IDA:BHF-UCL
- identical protein binding : IDA:BHF-UCL
- lipid binding : IDA:UniProtKB
- lipid transporter activity : IDA:BHF-UCL
- lipoprotein particle binding : IEA:Ensembl
- low-density lipoprotein particle receptor binding : IDA:BHF-UCL
- metal chelating activity : IDA:BHF-UCL
- phosphatidylcholine-sterol O-acyltransferase activator activity : IDA:BHF-UCL
- phospholipid binding : IDA:BHF-UCL
- protein dimerization activity : IDA:ARUK-UCL
- protein homodimerization activity : IDA:ARUK-UCL
- structural molecule activity : TAS:ARUK-UCL
- tau protein binding : IPI:BHF-UCL
- very-low-density lipoprotein particle receptor binding : IDA:BHF-UCL
|
| GO - Biological process |
- AMPA glutamate receptor clustering : IDA:Alzheimers_University_of_Toronto
- amyloid precursor protein metabolic process : IDA:UniProtKB
- artery morphogenesis : IEA:Ensembl
- cellular calcium ion homeostasis : IEA:Ensembl
- cellular protein metabolic process : TAS:Reactome
- cGMP-mediated signaling : IDA:BHF-UCL
- cholesterol catabolic process : IBA:GO_Central
- cholesterol efflux : IDA:BHF-UCL
- cholesterol homeostasis : IDA:BHF-UCL
- cholesterol metabolic process : IDA:BHF-UCL
- chylomicron assembly : TAS:Reactome
- chylomicron remnant clearance : IMP:BHF-UCL
- chylomicron remodeling : TAS:Reactome
- cytoskeleton organization : TAS:UniProtKB
- fatty acid homeostasis : IDA:Alzheimers_University_of_Toronto
- G-protein coupled receptor signaling pathway : IDA:BHF-UCL
- high-density lipoprotein particle assembly : IDA:BHF-UCL
- high-density lipoprotein particle clearance : IDA:BHF-UCL
- high-density lipoprotein particle remodeling : IGI:BHF-UCL
- intracellular transport : TAS:UniProtKB
- lipid transport involved in lipid storage : ISS:BHF-UCL
- lipoprotein biosynthetic process : IEA:Ensembl
- lipoprotein catabolic process : IBA:GO_Central
- locomotory exploration behavior : IMP:ARUK-UCL
- long-chain fatty acid transport : IDA:Alzheimers_University_of_Toronto
- long-term memory : IGI:ARUK-UCL
- low-density lipoprotein particle remodeling : IEA:Ensembl
- maintenance of location in cell : IEA:Ensembl
- negative regulation of amyloid-beta formation : IDA:Alzheimers_University_of_Toronto
- negative regulation of blood coagulation : IDA:BHF-UCL
- negative regulation of blood vessel endothelial cell migration : IDA:BHF-UCL
- negative regulation of canonical Wnt signaling pathway : IDA:ARUK-UCL
- negative regulation of cellular protein metabolic process : IGI:ARUK-UCL
- negative regulation of cholesterol biosynthetic process : IDA:BHF-UCL
- negative regulation of cholesterol efflux : IDA:Alzheimers_University_of_Toronto
- negative regulation of dendritic spine development : IDA:Alzheimers_University_of_Toronto
- negative regulation of dendritic spine maintenance : IDA:Alzheimers_University_of_Toronto
- negative regulation of endothelial cell proliferation : IDA:BHF-UCL
- negative regulation of gene expression : ISS:ARUK-UCL
- negative regulation of inflammatory response : IC:BHF-UCL
- negative regulation of lipid biosynthetic process : IDA:Alzheimers_University_of_Toronto
- negative regulation of lipid transport across blood brain barrier : IDA:Alzheimers_University_of_Toronto
- negative regulation of long-term synaptic potentiation : IDA:ARUK-UCL
- negative regulation of MAP kinase activity : IDA:BHF-UCL
- negative regulation of neuron apoptotic process : IBA:GO_Central
- negative regulation of neuron death : IDA:Alzheimers_University_of_Toronto
- negative regulation of neuron projection development : IDA:ARUK-UCL
- negative regulation of phospholipid efflux : IDA:Alzheimers_University_of_Toronto
- negative regulation of platelet activation : IDA:BHF-UCL
- negative regulation of postsynaptic membrane organization : IDA:Alzheimers_University_of_Toronto
- negative regulation of presynaptic membrane organization : IDA:Alzheimers_University_of_Toronto
- negative regulation of triglyceride metabolic process : IEA:Ensembl
- neuron projection regeneration : IBA:GO_Central
- nitric oxide mediated signal transduction : IDA:BHF-UCL
- NMDA glutamate receptor clustering : IDA:Alzheimers_University_of_Toronto
- phospholipid efflux : IDA:BHF-UCL
- positive regulation by host of viral process : IMP:AgBase
- positive regulation of amyloid fibril formation : TAS:ARUK-UCL
- positive regulation of amyloid-beta formation : IDA:Alzheimers_University_of_Toronto
- positive regulation of cGMP biosynthetic process : IDA:BHF-UCL
- positive regulation of cholesterol efflux : IDA:Alzheimers_University_of_Toronto
- positive regulation of cholesterol esterification : IDA:BHF-UCL
- positive regulation of dendritic spine development : IDA:Alzheimers_University_of_Toronto
- positive regulation of dendritic spine maintenance : IDA:Alzheimers_University_of_Toronto
- positive regulation of endocytosis : IDA:ARUK-UCL
- positive regulation of heparan sulfate binding : IDA:ARUK-UCL
- positive regulation of heparan sulfate proteoglycan binding : IDA:ARUK-UCL
- positive regulation of lipid biosynthetic process : IDA:Alzheimers_University_of_Toronto
- positive regulation of lipid transport across blood brain barrier : IDA:Alzheimers_University_of_Toronto
- positive regulation of low-density lipoprotein particle receptor catabolic process : IDA:BHF-UCL
- positive regulation of membrane protein ectodomain proteolysis : IDA:BHF-UCL
- positive regulation of neurofibrillary tangle assembly : IDA:Alzheimers_University_of_Toronto
- positive regulation of neuron death : IDA:Alzheimers_University_of_Toronto
- positive regulation of neuron projection development : IDA:ARUK-UCL
- positive regulation of nitric-oxide synthase activity : IDA:BHF-UCL
- positive regulation of phospholipid efflux : IDA:Alzheimers_University_of_Toronto
- positive regulation of postsynaptic membrane organization : IDA:Alzheimers_University_of_Toronto
- positive regulation of presynaptic membrane organization : IDA:Alzheimers_University_of_Toronto
- post-translational protein modification : TAS:Reactome
- protein import : IDA:Alzheimers_University_of_Toronto
- receptor-mediated endocytosis : IDA:BHF-UCL
- regulation of amyloid fibril formation : IDA:ARUK-UCL
- regulation of amyloid-beta clearance : IDA:Alzheimers_University_of_Toronto
- regulation of axon extension : TAS:UniProtKB
- regulation of behavioral fear response : IMP:ARUK-UCL
- regulation of Cdc42 protein signal transduction : IDA:BHF-UCL
- regulation of cellular response to very-low-density lipoprotein particle stimulus : IDA:ARUK-UCL
- regulation of cholesterol metabolic process : IGI:ARUK-UCL
- regulation of neuron death : IDA:Alzheimers_University_of_Toronto
- regulation of neuronal synaptic plasticity : TAS:UniProtKB
- regulation of protein homooligomerization : IDA:ARUK-UCL
- regulation of protein metabolic process : IGI:ARUK-UCL
- regulation of tau-protein kinase activity : IDA:Alzheimers_University_of_Toronto
- regulation of transcription by RNA polymerase II : TAS:Reactome
- response to caloric restriction : IGI:ARUK-UCL
- response to dietary excess : IEA:Ensembl
- response to reactive oxygen species : NAS:UniProtKB
- retinoid metabolic process : TAS:Reactome
- reverse cholesterol transport : IDA:BHF-UCL
- synaptic transmission, cholinergic : TAS:UniProtKB
- triglyceride catabolic process : IBA:GO_Central
- triglyceride homeostasis : ISS:BHF-UCL
- triglyceride metabolic process : IDA:BHF-UCL
- vasodilation : IEA:Ensembl
- very-low-density lipoprotein particle clearance : IDA:BHF-UCL
- very-low-density lipoprotein particle remodeling : IDA:BHF-UCL
- virion assembly : IMP:AgBase
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