Laminin subunit beta-1 (P02469)

Uniprot ID P02469
Protein Name Laminin subunit beta-1
Gene Name Lamb1
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.432
Function Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity). .
GO - Molecular function
  • enzyme binding : IPI:MGI
  • extracellular matrix structural constituent : ISS:HGNC-UCL
  • glycosphingolipid binding : IDA:MGI
  • integrin binding : IMP:MGI
GO - Biological process
  • animal organ morphogenesis : IBA:GO_Central
  • basement membrane assembly : IBA:GO_Central
  • cell migration : IMP:MGI
  • embryo implantation : IMP:MGI
  • learning or memory : NAS:UniProtKB
  • negative regulation of cell adhesion : IDA:UniProtKB
  • neuron projection development : IDA:MGI
  • neuronal-glial interaction involved in cerebral cortex radial glia guided migration : ISO:MGI
  • odontogenesis : ISS:HGNC-UCL
  • positive regulation of cell migration : ISS:HGNC-UCL
  • substrate adhesion-dependent cell spreading : ISO:MGI
  • tissue development : IBA:GO_Central
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.