Collagen alpha-2(I) chain (P02466)

Uniprot ID P02466
Protein Name Collagen alpha-2(I) chain
Gene Name Col1a2
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO - Molecular function
  • extracellular matrix structural constituent : IBA:GO_Central
  • identical protein binding : ISO:RGD
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : ISO:RGD
  • protease binding : ISO:RGD
  • protein binding, bridging : ISO:RGD
  • SMAD binding : ISO:RGD
GO - Biological process
  • blood vessel development : ISO:RGD
  • bone mineralization : ISO:RGD
  • cellular response to amino acid stimulus : ISO:RGD
  • cellular response to organic substance : IEP:RGD
  • cellular response to retinoic acid : IEP:RGD
  • cellular response to thyroid hormone stimulus : IEP:RGD
  • collagen fibril organization : ISO:RGD
  • collagen metabolic process : ISO:RGD
  • extracellular matrix assembly : ISO:RGD
  • extracellular matrix organization : IBA:GO_Central
  • protein heterotrimerization : ISO:RGD
  • regulation of blood pressure : ISO:RGD
  • response to norepinephrine : IEP:RGD
  • Rho protein signal transduction : ISO:RGD
  • skeletal system development : ISO:RGD
  • skin morphogenesis : ISO:RGD
  • transforming growth factor beta receptor signaling pathway : ISO:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.