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P02463

Collagen alpha-1(IV) chain (P02463)

Uniprot ID P02463
Protein Name Collagen alpha-1(IV) chain
Gene Name Col4a1
Species Mus musculus (Mouse)
Basic Information Experiments (4) Disease (9) Interactions
Signal peptide(a) Y Secretome P(b) 0.056
Function Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. .Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin. {ECO:0000250|UniProtKB:P02462}.
GO - Molecular function
  • extracellular matrix structural constituent : ISO:MGI
  • platelet-derived growth factor binding : ISO:MGI
GO - Biological process
  • basement membrane organization : ISO:MGI
  • blood vessel morphogenesis : ISO:MGI
  • brain development : ISO:MGI
  • branching involved in blood vessel morphogenesis : ISO:MGI
  • cellular response to amino acid stimulus : IDA:MGI
  • collagen-activated tyrosine kinase receptor signaling pathway : IGI:MGI
  • epithelial cell differentiation : IEA:Ensembl
  • neuromuscular junction development : IMP:MGI
  • renal tubule morphogenesis : ISO:MGI
  • retinal blood vessel morphogenesis : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.