Collagen alpha-1(I) chain (P02454)

Uniprot ID P02454
Protein Name Collagen alpha-1(I) chain
Gene Name Col1a1
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function Type I collagen is a member of group I collagen (fibrillar forming collagen).
GO - Molecular function
  • extracellular matrix structural constituent : ISO:RGD
  • identical protein binding : ISO:RGD
  • metal ion binding : IEA:UniProtKB-KW
  • platelet-derived growth factor binding : ISO:RGD
  • protease binding : ISO:RGD
GO - Biological process
  • blood vessel development : ISO:RGD
  • bone trabecula formation : ISO:RGD
  • cartilage development involved in endochondral bone morphogenesis : ISO:RGD
  • cellular response to amino acid stimulus : ISO:RGD
  • cellular response to epidermal growth factor stimulus : IEP:RGD
  • cellular response to fibroblast growth factor stimulus : IEP:RGD
  • cellular response to fluoride : IEP:RGD
  • cellular response to mechanical stimulus : IEP:RGD
  • cellular response to retinoic acid : IEP:RGD
  • cellular response to transforming growth factor beta stimulus : IEP:UniProtKB
  • cellular response to tumor necrosis factor : IEP:RGD
  • cellular response to vitamin E : IEP:RGD
  • collagen biosynthetic process : ISO:RGD
  • collagen fibril organization : ISO:RGD
  • collagen-activated tyrosine kinase receptor signaling pathway : IDA:MGI
  • embryonic skeletal system development : ISO:RGD
  • endochondral ossification : ISO:RGD
  • extracellular matrix organization : IBA:GO_Central
  • face morphogenesis : ISO:RGD
  • intramembranous ossification : ISO:RGD
  • negative regulation of cell-substrate adhesion : ISO:RGD
  • ossification : IEP:RGD
  • osteoblast differentiation : ISO:RGD
  • positive regulation of canonical Wnt signaling pathway : ISO:RGD
  • positive regulation of cell migration : ISO:RGD
  • positive regulation of epithelial to mesenchymal transition : ISO:RGD
  • positive regulation of transcription, DNA-templated : ISO:RGD
  • protein heterotrimerization : ISO:RGD
  • protein localization to nucleus : ISO:RGD
  • protein transport : ISO:RGD
  • response to cAMP : IEP:RGD
  • response to corticosteroid : IEP:RGD
  • response to drug : IEP:RGD
  • response to estradiol : IEP:RGD
  • response to fluoride : IEP:RGD
  • response to hydrogen peroxide : IEP:RGD
  • response to hyperoxia : IEP:RGD
  • response to mechanical stimulus : IEP:RGD
  • response to nutrient : IEP:RGD
  • response to nutrient levels : IEP:RGD
  • response to peptide hormone : IEP:RGD
  • response to steroid hormone : IEP:RGD
  • sensory perception of sound : ISO:RGD
  • skeletal system development : ISO:RGD
  • skeletal system morphogenesis : ISO:RGD
  • skin development : ISO:RGD
  • skin morphogenesis : ISO:RGD
  • tooth eruption : IEP:RGD
  • tooth mineralization : ISO:RGD
  • visual perception : ISO:RGD
  • wound healing : IMP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.