Histone H3.3C (P02301)

Uniprot ID P02301
Protein Name Histone H3.3C
Gene Name H3f3c
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.0
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
GO - Molecular function
  • DNA binding : IEA:UniProtKB-KW
  • protein heterodimerization activity : IEA:InterPro
GO - Biological process
  • nucleosome assembly : ISO:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.