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P01887

Beta-2-microglobulin (P01887)

Uniprot ID P01887
Protein Name Beta-2-microglobulin
Gene Name B2m
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.461
Function Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
GO - Molecular function
  • identical protein binding : ISO:MGI
GO - Biological process
  • antigen processing and presentation of endogenous peptide antigen via MHC class I : ISO:MGI
  • antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent : IMP:MGI
  • cellular defense response : TAS:MGI
  • cellular response to iron ion : ISO:MGI
  • cellular response to iron(III) ion : IMP:MGI
  • ferric iron import : IMP:MGI
  • immune response : IEA:InterPro
  • iron ion homeostasis : IMP:MGI
  • iron ion transport : IMP:MGI
  • negative regulation of neuron projection development : IGI:MGI
  • negative regulation of receptor binding : ISO:MGI
  • positive regulation of ferrous iron binding : ISO:MGI
  • positive regulation of protein binding : ISO:MGI
  • positive regulation of receptor binding : ISO:MGI
  • positive regulation of receptor-mediated endocytosis : ISO:MGI
  • positive regulation of T cell cytokine production : ISO:MGI
  • positive regulation of T cell mediated cytotoxicity : IMP:MGI
  • positive regulation of transferrin receptor binding : ISO:MGI
  • protein refolding : IDA:MGI
  • regulation of erythrocyte differentiation : IMP:MGI
  • regulation of iron ion import : ISO:MGI
  • response to cadmium ion : IEA:Ensembl
  • response to drug : IEA:Ensembl
  • response to molecule of bacterial origin : IMP:MGI
  • T cell differentiation in thymus : IGI:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.