| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). . |
| GO - Molecular function |
- cytokine activity : IDA:BHF-UCL
- integrin binding : IDA:UniProtKB
- interleukin-1 receptor binding : NAS:UniProtKB
- protein domain specific binding : IPI:UniProtKB
|
| GO - Biological process |
- activation of MAPK activity : IDA:BHF-UCL
- apoptotic process : TAS:ProtInc
- astrocyte activation : IEA:Ensembl
- cell-cell signaling : TAS:ProtInc
- cellular response to drug : IDA:MGI
- cellular response to lipopolysaccharide : IBA:GO_Central
- cellular response to mechanical stimulus : IEP:UniProtKB
- cellular response to organic cyclic compound : IDA:UniProtKB
- cellular response to organic substance : IDA:MGI
- cytokine-mediated signaling pathway : IDA:BHF-UCL
- ectopic germ cell programmed cell death : IEA:Ensembl
- embryo implantation : TAS:BHF-UCL
- extrinsic apoptotic signaling pathway in absence of ligand : IEA:Ensembl
- fever generation : IEA:UniProtKB-KW
- hyaluronan biosynthetic process : IDA:UniProtKB
- inflammatory response : IDA:UniProtKB
- inflammatory response to antigenic stimulus : IBA:GO_Central
- interleukin-1 beta production : IEA:Ensembl
- interleukin-1-mediated signaling pathway : IDA:BHF-UCL
- interleukin-6 production : IEA:Ensembl
- lipopolysaccharide-mediated signaling pathway : IDA:UniProtKB
- MAPK cascade : IMP:UniProtKB
- monocyte aggregation : IDA:UniProtKB
- negative regulation of adiponectin secretion : ISS:BHF-UCL
- negative regulation of cell population proliferation : IDA:BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IDA:BHF-UCL
- negative regulation of gap junction assembly : IDA:ARUK-UCL
- negative regulation of glucose transmembrane transport : ISS:BHF-UCL
- negative regulation of insulin receptor signaling pathway : ISS:BHF-UCL
- negative regulation of lipid catabolic process : IDA:BHF-UCL
- negative regulation of lipid metabolic process : ISS:BHF-UCL
- negative regulation of MAP kinase activity : ISS:BHF-UCL
- negative regulation of neurogenesis : TAS:ARUK-UCL
- negative regulation of synaptic transmission : ISS:ARUK-UCL
- neutrophil chemotaxis : IEA:Ensembl
- positive regulation of angiogenesis : IDA:BHF-UCL
- positive regulation of calcidiol 1-monooxygenase activity : IDA:BHF-UCL
- positive regulation of cell adhesion molecule production : NAS:BHF-UCL
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell migration : IDA:BHF-UCL
- positive regulation of cell population proliferation : IDA:BHF-UCL
- positive regulation of chemokine biosynthetic process : IEA:Ensembl
- positive regulation of complement activation : IGI:ARUK-UCL
- positive regulation of DNA-binding transcription factor activity : IDA:BHF-UCL
- positive regulation of epithelial to mesenchymal transition : IDA:BHF-UCL
- positive regulation of fever generation : ISS:BHF-UCL
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of glial cell proliferation : IGI:ARUK-UCL
- positive regulation of granulocyte macrophage colony-stimulating factor production : IDA:BHF-UCL
- positive regulation of heterotypic cell-cell adhesion : IDA:UniProtKB
- positive regulation of histone acetylation : NAS:BHF-UCL
- positive regulation of histone phosphorylation : NAS:BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IBA:GO_Central
- positive regulation of immature T cell proliferation in thymus : IBA:GO_Central
- positive regulation of inflammatory response : IGI:ARUK-UCL
- positive regulation of interferon-gamma production : IDA:UniProtKB
- positive regulation of interleukin-2 biosynthetic process : IMP:BHF-UCL
- positive regulation of interleukin-6 biosynthetic process : IEA:Ensembl
- positive regulation of interleukin-6 production : IGI:ARUK-UCL
- positive regulation of interleukin-6 secretion : IEA:Ensembl
- positive regulation of interleukin-8 production : IDA:UniProtKB
- positive regulation of JNK cascade : ISS:ARUK-UCL
- positive regulation of lipid catabolic process : ISS:BHF-UCL
- positive regulation of membrane protein ectodomain proteolysis : IDA:BHF-UCL
- positive regulation of mitotic nuclear division : IMP:BHF-UCL
- positive regulation of monocyte chemotactic protein-1 production : IDA:UniProtKB
- positive regulation of myosin light chain kinase activity : IDA:BHF-UCL
- positive regulation of neuroinflammatory response : TAS:ARUK-UCL
- positive regulation of NF-kappaB transcription factor activity : IDA:BHF-UCL
- positive regulation of NIK/NF-kappaB signaling : IDA:BHF-UCL
- positive regulation of nitric oxide biosynthetic process : IDA:BHF-UCL
- positive regulation of p38MAPK cascade : ISS:ARUK-UCL
- positive regulation of phagocytosis : IMP:AgBase
- positive regulation of prostaglandin biosynthetic process : IGI:ARUK-UCL
- positive regulation of prostaglandin secretion : ISS:BHF-UCL
- positive regulation of protein export from nucleus : NAS:BHF-UCL
- positive regulation of protein phosphorylation : IDA:BHF-UCL
- positive regulation of RNA biosynthetic process : IDA:ARUK-UCL
- positive regulation of T cell mediated immunity : IC:BHF-UCL
- positive regulation of T cell proliferation : IDA:BHF-UCL
- positive regulation of T-helper 1 cell cytokine production : IDA:UniProtKB
- positive regulation of transcription by RNA polymerase II : IEA:Ensembl
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- positive regulation of vascular endothelial growth factor production : IDA:BHF-UCL
- positive regulation of vascular endothelial growth factor receptor signaling pathway : IC:BHF-UCL
- protein kinase B signaling : IMP:UniProtKB
- regulation of defense response to virus by host : IEA:Ensembl
- regulation of ERK1 and ERK2 cascade : IDA:BHF-UCL
- regulation of establishment of endothelial barrier : IDA:UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling : IDA:BHF-UCL
- regulation of insulin secretion : IDA:BHF-UCL
- regulation of neurogenesis : ISS:ARUK-UCL
- regulation of nitric-oxide synthase activity : IDA:UniProtKB
- response to ATP : IEA:Ensembl
- response to carbohydrate : IEA:Ensembl
- response to interleukin-1 : IDA:ARUK-UCL
- response to lipopolysaccharide : IDA:ARUK-UCL
- sequestering of triglyceride : IDA:BHF-UCL
- signal transduction : TAS:ProtInc
- smooth muscle adaptation : NAS:BHF-UCL
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