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P01581

Interferon gamma (P01581)

Uniprot ID P01581
Protein Name Interferon gamma
Gene Name Ifng
Species Rattus norvegicus (Rat)
Basic Information Experiments (3) Disease (28) Interactions
Signal peptide(a) Y Secretome P(b)
Function Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
GO - Molecular function
  • cytokine activity : ISO:RGD
  • interferon-gamma receptor binding : IEA:InterPro
GO - Biological process
  • adaptive immune response : ISO:RGD
  • antigen processing and presentation : ISO:RGD
  • apoptotic process : ISO:RGD
  • astrocyte activation : ISO:RGD
  • CD8-positive, alpha-beta T cell differentiation involved in immune response : ISO:RGD
  • cell cycle arrest : ISO:RGD
  • cellular response to interleukin-18 : ISO:RGD
  • cellular response to lipopolysaccharide : ISO:RGD
  • defense response to bacterium : ISO:RGD
  • defense response to protozoan : ISO:RGD
  • defense response to virus : ISO:RGD
  • endoplasmic reticulum unfolded protein response : ISO:RGD
  • extrinsic apoptotic signaling pathway : ISO:RGD
  • humoral immune response : ISO:RGD
  • inflammatory cell apoptotic process : ISO:RGD
  • interferon-gamma-mediated signaling pathway : ISO:RGD
  • microglial cell activation : IGI:ARUK-UCL
  • negative regulation of amyloid-beta clearance : ISO:RGD
  • negative regulation of cell population proliferation : IDA:RGD
  • negative regulation of epithelial cell differentiation : IDA:BHF-UCL
  • negative regulation of fibroblast proliferation : IDA:RGD
  • negative regulation of gene expression : ISO:RGD
  • negative regulation of glomerular mesangial cell proliferation : IMP:RGD
  • negative regulation of interleukin-17 production : ISO:RGD
  • negative regulation of myelination : ISO:RGD
  • negative regulation of osteoclast differentiation : ISO:RGD
  • negative regulation of smooth muscle cell proliferation : ISO:RGD
  • negative regulation of tau-protein kinase activity : ISO:RGD
  • negative regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • negative regulation of transcription, DNA-templated : ISO:RGD
  • neuroinflammatory response : IDA:ARUK-UCL
  • neutrophil apoptotic process : ISO:RGD
  • neutrophil chemotaxis : ISO:RGD
  • positive regulation by host of viral process : ISO:RGD
  • positive regulation of amyloid-beta formation : ISO:RGD
  • positive regulation of apoptotic process : IDA:RGD
  • positive regulation of autophagy : ISS:UniProtKB
  • positive regulation of calcidiol 1-monooxygenase activity : ISO:RGD
  • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response : ISO:RGD
  • positive regulation of cell adhesion : IDA:RGD
  • positive regulation of cell population proliferation : IDA:BHF-UCL
  • positive regulation of cellular respiration : ISO:RGD
  • positive regulation of chemokine biosynthetic process : ISO:RGD
  • positive regulation of core promoter binding : ISO:RGD
  • positive regulation of epithelial cell migration : ISO:RGD
  • positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity : ISO:RGD
  • positive regulation of fructose 1,6-bisphosphate metabolic process : ISO:RGD
  • positive regulation of gene expression : IDA:ARUK-UCL
  • positive regulation of glycolytic process : ISO:RGD
  • positive regulation of interleukin-1 beta biosynthetic process : ISO:RGD
  • positive regulation of interleukin-1 beta secretion : ISO:RGD
  • positive regulation of interleukin-12 biosynthetic process : ISO:RGD
  • positive regulation of interleukin-12 production : ISO:RGD
  • positive regulation of interleukin-23 production : ISO:RGD
  • positive regulation of interleukin-6 biosynthetic process : ISO:RGD
  • positive regulation of iron ion import across plasma membrane : ISO:RGD
  • positive regulation of isotype switching to IgG isotypes : ISO:RGD
  • positive regulation of killing of cells of other organism : ISO:RGD
  • positive regulation of membrane protein ectodomain proteolysis : ISO:RGD
  • positive regulation of MHC class II biosynthetic process : IEP:RGD
  • positive regulation of neurogenesis : ISO:RGD
  • positive regulation of neuron death : ISO:RGD
  • positive regulation of neuron differentiation : IDA:RGD
  • positive regulation of nitric oxide biosynthetic process : ISO:RGD
  • positive regulation of nitric-oxide synthase biosynthetic process : ISO:RGD
  • positive regulation of nitrogen compound metabolic process : ISO:RGD
  • positive regulation of NMDA glutamate receptor activity : IGI:ARUK-UCL
  • positive regulation of osteoclast differentiation : ISO:RGD
  • positive regulation of peptidyl-serine phosphorylation of STAT protein : IDA:BHF-UCL
  • positive regulation of phagocytosis : ISO:RGD
  • positive regulation of protein deacetylation : ISO:RGD
  • positive regulation of protein import into nucleus : ISO:RGD
  • positive regulation of protein phosphorylation : ISO:RGD
  • positive regulation of protein serine/threonine kinase activity : ISO:RGD
  • positive regulation of protein-containing complex assembly : ISO:RGD
  • positive regulation of receptor biosynthetic process : ISO:RGD
  • positive regulation of smooth muscle cell apoptotic process : ISO:RGD
  • positive regulation of synaptic transmission, cholinergic : IDA:RGD
  • positive regulation of T cell proliferation : ISO:RGD
  • positive regulation of transcription by RNA polymerase II : ISO:RGD
  • positive regulation of transcription, DNA-templated : ISO:RGD
  • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production : ISO:RGD
  • positive regulation of tumor necrosis factor biosynthetic process : ISO:RGD
  • positive regulation of tumor necrosis factor production : ISO:RGD
  • positive regulation of tumor necrosis factor secretion : ISO:RGD
  • positive regulation of tyrosine phosphorylation of STAT protein : IDA:BHF-UCL
  • positive regulation of vitamin D biosynthetic process : ISO:RGD
  • receptor signaling pathway via JAK-STAT : ISO:RGD
  • regulation of defense response to virus by host : ISO:RGD
  • regulation of glial cell proliferation : IDA:RGD
  • regulation of growth : IEA:UniProtKB-KW
  • regulation of hepatocyte proliferation : IDA:RGD
  • regulation of immune response : ISO:RGD
  • regulation of insulin secretion : ISO:RGD
  • regulation of neuronal action potential : IDA:RGD
  • regulation of protein ADP-ribosylation : ISO:RGD
  • regulation of the force of heart contraction : IDA:RGD
  • regulation of transcription, DNA-templated : ISO:RGD
  • response to drug : IEP:RGD
  • response to virus : ISO:RGD
  • sensory perception of mechanical stimulus : IDA:RGD
  • T cell receptor signaling pathway : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.