Signal peptide(a) |
N |
Secretome P(b) |
0.894 |
Function |
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). .The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000269|PubMed:16829952}. |
GO - Molecular function |
- cytokine activity : IDA:BHF-UCL
- identical protein binding : IDA:BHF-UCL
- protease binding : IPI:BHF-UCL
- transcription regulatory region DNA binding : IDA:UniProtKB
- tumor necrosis factor receptor binding : IDA:BHF-UCL
|
GO - Biological process |
- activation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:UniProtKB
- activation of MAPK activity : IDA:BHF-UCL
- activation of MAPKKK activity : IDA:BHF-UCL
- astrocyte activation : NAS:ARUK-UCL
- cellular response to amino acid stimulus : IEA:Ensembl
- cellular response to nicotine : IDA:UniProtKB
- cellular response to organic cyclic compound : IDA:UniProtKB
- chronic inflammatory response to antigenic stimulus : IMP:BHF-UCL
- cognition : TAS:ARUK-UCL
- cortical actin cytoskeleton organization : IDA:UniProtKB
- cytokine-mediated signaling pathway : TAS:Reactome
- death-inducing signaling complex assembly : TAS:Reactome
- defense response to Gram-positive bacterium : IEA:Ensembl
- embryonic digestive tract development : IEP:DFLAT
- endothelial cell apoptotic process : IEA:Ensembl
- epithelial cell proliferation involved in salivary gland morphogenesis : IEA:Ensembl
- extracellular matrix organization : IEA:Ensembl
- extrinsic apoptotic signaling pathway : IDA:UniProtKB
- extrinsic apoptotic signaling pathway via death domain receptors : IDA:UniProtKB
- glucose metabolic process : IEA:Ensembl
- humoral immune response : IEA:Ensembl
- I-kappaB kinase/NF-kappaB signaling : TAS:Reactome
- inflammatory response : IDA:UniProtKB
- intrinsic apoptotic signaling pathway in response to DNA damage : IEA:Ensembl
- JNK cascade : IEA:Ensembl
- leukocyte tethering or rolling : IDA:BHF-UCL
- lipopolysaccharide-mediated signaling pathway : IDA:UniProtKB
- MAPK cascade : IMP:UniProtKB
- microglial cell activation : ISS:ARUK-UCL
- necroptotic signaling pathway : IDA:UniProtKB
- negative regulation of alkaline phosphatase activity : IEA:Ensembl
- negative regulation of amyloid-beta clearance : ISS:ARUK-UCL
- negative regulation of bicellular tight junction assembly : IDA:UniProtKB
- negative regulation of branching involved in lung morphogenesis : IDA:UniProtKB
- negative regulation of cytokine secretion involved in immune response : IDA:BHF-UCL
- negative regulation of endothelial cell proliferation : IEA:Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IDA:BHF-UCL
- negative regulation of fat cell differentiation : NAS:BHF-UCL
- negative regulation of gene expression : IDA:UniProtKB
- negative regulation of glucose import : IEA:Ensembl
- negative regulation of interleukin-6 production : IDA:BHF-UCL
- negative regulation of lipid catabolic process : IDA:BHF-UCL
- negative regulation of lipid storage : NAS:BHF-UCL
- negative regulation of mitotic cell cycle : IEA:Ensembl
- negative regulation of myoblast differentiation : IEA:Ensembl
- negative regulation of myosin-light-chain-phosphatase activity : IDA:UniProtKB
- negative regulation of neurogenesis : TAS:ARUK-UCL
- negative regulation of osteoblast differentiation : IEA:Ensembl
- negative regulation of protein complex disassembly : IDA:UniProtKB
- negative regulation of transcription by RNA polymerase II : IDA:UniProtKB
- negative regulation of transcription, DNA-templated : IDA:UniProtKB
- negative regulation of viral genome replication : IDA:BHF-UCL
- osteoclast differentiation : IEA:Ensembl
- positive regulation of amyloid-beta formation : ISS:ARUK-UCL
- positive regulation of apoptotic process : IDA:UniProtKB
- positive regulation of blood microparticle formation : IDA:BHF-UCL
- positive regulation of calcidiol 1-monooxygenase activity : IDA:BHF-UCL
- positive regulation of calcineurin-NFAT signaling cascade : IDA:MGI
- positive regulation of cell adhesion : IMP:UniProtKB
- positive regulation of ceramide biosynthetic process : TAS:Reactome
- positive regulation of chemokine (C-X-C motif) ligand 2 production : IDA:BHF-UCL
- positive regulation of chemokine biosynthetic process : IDA:BHF-UCL
- positive regulation of chemokine production : IDA:BHF-UCL
- positive regulation of chemokine secretion : ISS:ARUK-UCL
- positive regulation of chronic inflammatory response to antigenic stimulus : IEA:Ensembl
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:UniProtKB
- positive regulation of cytokine production : IDA:BHF-UCL
- positive regulation of cytokine secretion : IDA:BHF-UCL
- positive regulation of DNA-binding transcription factor activity : IDA:BHF-UCL
- positive regulation of ERK1 and ERK2 cascade : NAS:BHF-UCL
- positive regulation of fever generation : ISS:BHF-UCL
- positive regulation of fractalkine biosynthetic process : ISS:ARUK-UCL
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of glial cell proliferation : IDA:ARUK-UCL
- positive regulation of hair follicle development : IEA:Ensembl
- positive regulation of heterotypic cell-cell adhesion : IDA:BHF-UCL
- positive regulation of humoral immune response mediated by circulating immunoglobulin : IEA:Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IDA:BHF-UCL
- positive regulation of inflammatory response : TAS:ARUK-UCL
- positive regulation of interferon-gamma production : IEA:Ensembl
- positive regulation of interleukin-6 biosynthetic process : ISS:ARUK-UCL
- positive regulation of interleukin-6 production : IDA:ARUK-UCL
- positive regulation of interleukin-6 secretion : ISS:ARUK-UCL
- positive regulation of interleukin-8 biosynthetic process : IDA:BHF-UCL
- positive regulation of interleukin-8 production : IMP:UniProtKB
- positive regulation of JUN kinase activity : IDA:UniProtKB
- positive regulation of leukocyte adhesion to arterial endothelial cell : IDA:BHF-UCL
- positive regulation of leukocyte adhesion to vascular endothelial cell : IDA:BHF-UCL
- positive regulation of MAP kinase activity : IDA:UniProtKB
- positive regulation of membrane protein ectodomain proteolysis : IDA:BHF-UCL
- positive regulation of mononuclear cell migration : NAS:BHF-UCL
- positive regulation of neuroinflammatory response : TAS:ARUK-UCL
- positive regulation of neuron apoptotic process : ISS:ARUK-UCL
- positive regulation of NF-kappaB transcription factor activity : IDA:UniProtKB
- positive regulation of NIK/NF-kappaB signaling : IDA:UniProtKB
- positive regulation of nitric oxide biosynthetic process : IDA:BHF-UCL
- positive regulation of nitric-oxide synthase activity : IC:ARUK-UCL
- positive regulation of nitrogen compound metabolic process : ISS:ARUK-UCL
- positive regulation of osteoclast differentiation : IDA:BHF-UCL
- positive regulation of peptidyl-serine phosphorylation : IDA:BHF-UCL
- positive regulation of phagocytosis : IMP:AgBase
- positive regulation of phosphatidylinositol 3-kinase signaling : ISS:ARUK-UCL
- positive regulation of podosome assembly : IDA:BHF-UCL
- positive regulation of programmed cell death : IDA:UniProtKB
- positive regulation of protein catabolic process : IDA:AgBase
- positive regulation of protein complex assembly : IDA:BHF-UCL
- positive regulation of protein complex disassembly : IDA:UniProtKB
- positive regulation of protein kinase activity : IDA:AgBase
- positive regulation of protein kinase B signaling : ISS:ARUK-UCL
- positive regulation of protein localization to cell surface : IDA:BHF-UCL
- positive regulation of protein localization to plasma membrane : ISS:ARUK-UCL
- positive regulation of protein phosphorylation : IDA:UniProtKB
- positive regulation of protein transport : IDA:BHF-UCL
- positive regulation of receptor signaling pathway via JAK-STAT : ISS:ARUK-UCL
- positive regulation of smooth muscle cell proliferation : IDA:BHF-UCL
- positive regulation of superoxide dismutase activity : IDA:BHF-UCL
- positive regulation of synaptic transmission : ISS:ARUK-UCL
- positive regulation of transcription by RNA polymerase II : IDA:UniProtKB
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- positive regulation of translational initiation by iron : IEA:Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein : ISS:ARUK-UCL
- positive regulation of vascular smooth muscle cell proliferation : IEA:Ensembl
- positive regulation of vitamin D biosynthetic process : IDA:BHF-UCL
- protein kinase B signaling : IMP:UniProtKB
- protein localization to plasma membrane : IDA:UniProtKB
- receptor biosynthetic process : IDA:BHF-UCL
- regulation of branching involved in salivary gland morphogenesis : IEA:Ensembl
- regulation of endothelial cell apoptotic process : IMP:ARUK-UCL
- regulation of establishment of endothelial barrier : IDA:UniProtKB
- regulation of fat cell differentiation : ISS:ARUK-UCL
- regulation of I-kappaB kinase/NF-kappaB signaling : IDA:BHF-UCL
- regulation of immunoglobulin secretion : IEA:Ensembl
- regulation of insulin secretion : IDA:BHF-UCL
- regulation of synapse organization : ISS:ARUK-UCL
- regulation of synaptic transmission, glutamatergic : TAS:ARUK-UCL
- regulation of transcription by RNA polymerase II : ISS:ARUK-UCL
- regulation of tumor necrosis factor-mediated signaling pathway : TAS:Reactome
- response to glucocorticoid : IDA:BHF-UCL
- response to salt stress : TAS:BHF-UCL
- response to virus : IDA:BHF-UCL
- sequestering of triglyceride : IDA:BHF-UCL
- tumor necrosis factor-mediated signaling pathway : IMP:BHF-UCL
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