Beta-nerve growth factor (P01139)

Uniprot ID P01139
Protein Name Beta-nerve growth factor
Gene Name Ngf
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.884
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI. .
GO - Molecular function
  • growth factor activity : IBA:GO_Central
  • metalloendopeptidase inhibitor activity : ISS:UniProtKB
  • nerve growth factor receptor binding : ISO:MGI
  • transmembrane receptor protein tyrosine kinase activator activity : IDA:BHF-UCL
GO - Biological process
  • adult locomotory behavior : ISO:MGI
  • circadian rhythm : IEP:UniProtKB
  • extrinsic apoptotic signaling pathway in absence of ligand : IDA:MGI
  • extrinsic apoptotic signaling pathway via death domain receptors : ISO:MGI
  • memory : ISO:MGI
  • negative regulation of neuron apoptotic process : IGI:MGI
  • negative regulation of type B pancreatic cell apoptotic process : ISO:MGI
  • nerve growth factor signaling pathway : IDA:MGI
  • neuron apoptotic process : IMP:MGI
  • neuron development : IDA:MGI
  • neuron projection development : IDA:MGI
  • neuron projection morphogenesis : ISO:MGI
  • peripheral nervous system development : IMP:MGI
  • positive regulation of axon extension : IDA:MGI
  • positive regulation of cell growth : ISO:MGI
  • positive regulation of cell proliferation : ISO:MGI
  • positive regulation of collateral sprouting : IDA:MGI
  • positive regulation of DNA binding : IMP:ARUK-UCL
  • positive regulation of DNA binding transcription factor activity : ISO:MGI
  • positive regulation of gene expression : IGI:ARUK-UCL
  • positive regulation of neuron differentiation : ISO:MGI
  • positive regulation of neuron maturation : IDA:MGI
  • positive regulation of neuron projection development : IDA:MGI
  • positive regulation of neurotrophin TRK receptor signaling pathway : ISO:MGI
  • positive regulation of protein autophosphorylation : ISO:MGI
  • positive regulation of protein binding : ISO:MGI
  • positive regulation of protein phosphorylation : IDA:BHF-UCL
  • positive regulation of protein ubiquitination : IDA:MGI
  • positive regulation of Ras protein signal transduction : IDA:ParkinsonsUK-UCL
  • positive regulation of stem cell proliferation : ISO:MGI
  • regulation of neuron differentiation : IDA:MGI
  • regulation of neurotransmitter secretion : IGI:MGI
  • regulation of release of sequestered calcium ion into cytosol : IGI:MGI
  • sensory perception of pain : IMP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.