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P01138

Beta-nerve growth factor (P01138)

Uniprot ID P01138
Protein Name Beta-nerve growth factor
Gene Name NGF
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.806
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). .
GO - Molecular function
  • cysteine-type endopeptidase activator activity involved in apoptotic process : IGI:ARUK-UCL
  • death receptor agonist activity : IGI:ARUK-UCL
  • growth factor activity : IBA:GO_Central
  • metalloendopeptidase inhibitor activity : IDA:UniProtKB
  • nerve growth factor receptor binding : IPI:BHF-UCL
GO - Biological process
  • activation of cysteine-type endopeptidase activity involved in apoptotic process : IGI:ARUK-UCL
  • activation of MAPKK activity : TAS:Reactome
  • cell-cell signaling : IBA:GO_Central
  • extrinsic apoptotic signaling pathway via death domain receptors : IDA:BHF-UCL
  • negative regulation of apoptotic process : TAS:Reactome
  • negative regulation of cell proliferation : TAS:ARUK-UCL
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : TAS:Reactome
  • negative regulation of neuron apoptotic process : IBA:GO_Central
  • nerve growth factor processing : TAS:Reactome
  • neuron apoptotic process : IGI:ARUK-UCL
  • neuron projection morphogenesis : IDA:MGI
  • neurotrophin TRK receptor signaling pathway : TAS:Reactome
  • phosphatidylinositol-mediated signaling : TAS:Reactome
  • positive regulation of apoptotic process : TAS:Reactome
  • positive regulation of axonogenesis : TAS:Reactome
  • positive regulation of DNA binding : ISS:ARUK-UCL
  • positive regulation of gene expression : IMP:UniProtKB
  • positive regulation of neuron differentiation : TAS:ARUK-UCL
  • positive regulation of Ras protein signal transduction : ISS:ParkinsonsUK-UCL
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process : TAS:Reactome
  • regulation of neuron differentiation : IBA:GO_Central
  • transmembrane receptor protein tyrosine kinase signaling pathway : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.