Low-density lipoprotein receptor (P01130)

Uniprot ID	P01130
Protein Name	Low-density lipoprotein receptor
Gene Name	LDLR
Species	Homo sapiens (Human)

Signal peptide^(a)	Y	Secretome P^(b)	0.349
Function	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. .(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. {ECO:0000269\|PubMed:10535997, ECO:0000269\|PubMed:12615904}.(Microbial infection) Acts as a receptor for Vesicular stomatitis virus. {ECO:0000269\|PubMed:23589850}.(Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. {ECO:0000269\|PubMed:11100124}.
GO - Molecular function	amyloid-beta binding : IEA:Ensembl calcium ion binding : IEA:InterPro clathrin heavy chain binding : TAS:BHF-UCL identical protein binding : IPI:IntAct low-density lipoprotein particle binding : IMP:BHF-UCL low-density lipoprotein particle receptor activity : IDA:BHF-UCL protease binding : IPI:BHF-UCL very-low-density lipoprotein particle receptor activity : IDA:BHF-UCL virus receptor activity : IEA:UniProtKB-KW
GO - Biological process	amyloid-beta clearance : ISS:ARUK-UCL cellular response to fatty acid : IEA:Ensembl cellular response to low-density lipoprotein particle stimulus : IMP:BHF-UCL cholesterol homeostasis : IMP:BHF-UCL cholesterol import : IMP:BHF-UCL cholesterol metabolic process : IEA:UniProtKB-KW cholesterol transport : IMP:HGNC chylomicron remnant clearance : TAS:Reactome endocytosis : TAS:ProtInc intestinal cholesterol absorption : IMP:HGNC lipid metabolic process : TAS:ProtInc lipoprotein catabolic process : IEA:Ensembl long-term memory : IGI:ARUK-UCL low-density lipoprotein particle clearance : IMP:BHF-UCL membrane organization : TAS:Reactome negative regulation of amyloid fibril formation : ISS:ARUK-UCL negative regulation of astrocyte activation : ISS:ARUK-UCL negative regulation of gene expression : IEA:Ensembl negative regulation of microglial cell activation : ISS:ARUK-UCL negative regulation of protein metabolic process : ISS:ARUK-UCL phospholipid transport : ISS:BHF-UCL plasma lipoprotein particle clearance : TAS:ARUK-UCL positive regulation of amyloid-beta clearance : ISS:ARUK-UCL positive regulation of endocytosis : ISS:ARUK-UCL positive regulation of gene expression : IEA:Ensembl positive regulation of inflammatory response : IEA:Ensembl positive regulation of lipoprotein particle clearance : ISS:ARUK-UCL positive regulation of lysosomal protein catabolic process : ISS:ARUK-UCL positive regulation of triglyceride biosynthetic process : ISS:BHF-UCL receptor-mediated endocytosis : ISS:ARUK-UCL receptor-mediated endocytosis involved in cholesterol transport : IMP:BHF-UCL regulation of cholesterol metabolic process : IEA:Ensembl regulation of phosphatidylcholine catabolic process : ISS:BHF-UCL regulation of protein metabolic process : IGI:ARUK-UCL response to caloric restriction : IGI:ARUK-UCL

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}