Metalloproteinase inhibitor 1 (P01033)

Uniprot ID P01033
Protein Name Metalloproteinase inhibitor 1
Gene Name TIMP1
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.86
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. .
GO - Molecular function
  • cytokine activity : IDA:UniProtKB
  • growth factor activity : IEA:UniProtKB-KW
  • metalloendopeptidase inhibitor activity : IDA:UniProtKB
  • peptidase inhibitor activity : IDA:UniProtKB
  • protease binding : IBA:GO_Central
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • aging : IEA:Ensembl
  • cartilage development : IEA:Ensembl
  • cell activation : IEA:Ensembl
  • cellular protein metabolic process : TAS:Reactome
  • connective tissue replacement involved in inflammatory response wound healing : IEA:Ensembl
  • cytokine-mediated signaling pathway : TAS:Reactome
  • extracellular matrix disassembly : TAS:Reactome
  • negative regulation of apoptotic process : IEA:Ensembl
  • negative regulation of catalytic activity : IDA:UniProtKB
  • negative regulation of endopeptidase activity : IDA:UniProtKB
  • negative regulation of membrane protein ectodomain proteolysis : IDA:UniProtKB
  • negative regulation of metallopeptidase activity : IDA:UniProtKB
  • negative regulation of trophoblast cell migration : IMP:BHF-UCL
  • platelet degranulation : TAS:Reactome
  • positive regulation of cell population proliferation : IDA:UniProtKB
  • post-translational protein modification : TAS:Reactome
  • regulation of integrin-mediated signaling pathway : IMP:UniProtKB
  • response to cytokine : IBA:GO_Central
  • response to hormone : IBA:GO_Central
  • response to organic substance : IBA:GO_Central
  • response to peptide hormone : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.