Complement C3 (P01027)

Uniprot ID P01027
Protein Name Complement C3
Gene Name C3
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.475
Function C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity. .C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000250}.Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
GO - Molecular function
  • C5L2 anaphylatoxin chemotactic receptor binding : ISS:UniProtKB
  • cofactor binding : ISO:MGI
  • endopeptidase inhibitor activity : IEA:InterPro
  • lipid binding : ISO:MGI
GO - Biological process
  • amyloid-beta clearance : IMP:ARUK-UCL
  • blood coagulation : ISO:MGI
  • complement activation : IDA:MGI
  • complement activation, alternative pathway : IEA:UniProtKB-KW
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • fatty acid metabolic process : IEA:UniProtKB-KW
  • inflammatory response : IEA:UniProtKB-KW
  • phagocytosis, engulfment : IMP:ARUK-UCL
  • positive regulation of activation of membrane attack complex : IMP:BHF-UCL
  • positive regulation of angiogenesis : IMP:BHF-UCL
  • positive regulation of apoptotic cell clearance : ISO:MGI
  • positive regulation of developmental growth : ISO:MGI
  • positive regulation of ERK1 and ERK2 cascade : ISO:MGI
  • positive regulation of G-protein coupled receptor protein signaling pathway : ISS:UniProtKB
  • positive regulation of glucose transmembrane transport : ISS:UniProtKB
  • positive regulation of lipid storage : ISS:UniProtKB
  • positive regulation of phagocytosis : IMP:MGI
  • positive regulation of protein phosphorylation : ISS:UniProtKB
  • positive regulation of type IIa hypersensitivity : IMP:MGI
  • positive regulation of vascular endothelial growth factor production : ISO:MGI
  • regulation of triglyceride biosynthetic process : ISS:UniProtKB
  • response to bacterium : IEP:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.