Complement C3 (P01026)

Uniprot ID P01026
Protein Name Complement C3
Gene Name C3
Species Rattus norvegicus (Rat)
Signal peptide(a) Y Secretome P(b)
Function C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. .Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. In chronic inflammation, acts as a chemoattractant for neutrophils (PubMed:8352775). {ECO:0000269|PubMed:8352775}.[C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation. {ECO:0000269|PubMed:8352775}.[Acylation stimulating protein]: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (By similarity). {ECO:0000250}.
GO - Molecular function
  • C5L2 anaphylatoxin chemotactic receptor binding : ISS:UniProtKB
  • cofactor binding : IPI:RGD
  • endopeptidase inhibitor activity : IEA:InterPro
  • lipid binding : IDA:RGD
GO - Biological process
  • amyloid-beta clearance : ISO:RGD
  • blood coagulation : IMP:RGD
  • cell surface receptor signaling pathway involved in cell-cell signaling : ISO:RGD
  • chemotaxis : IEA:UniProtKB-KW
  • complement activation : IDA:RGD
  • complement activation, alternative pathway : IEA:UniProtKB-KW
  • complement activation, classical pathway : TAS:RGD
  • complement-dependent cytotoxicity : ISO:RGD
  • complement-mediated synapse pruning : ISO:RGD
  • fatty acid metabolic process : IEA:UniProtKB-KW
  • inflammatory response : IEA:UniProtKB-KW
  • neuron remodeling : ISO:RGD
  • positive regulation of activation of membrane attack complex : ISO:RGD
  • positive regulation of angiogenesis : ISO:RGD
  • positive regulation of apoptotic cell clearance : ISO:RGD
  • positive regulation of developmental growth : IDA:RGD
  • positive regulation of ERK1 and ERK2 cascade : IDA:RGD
  • positive regulation of G protein-coupled receptor signaling pathway : ISS:UniProtKB
  • positive regulation of glucose transmembrane transport : ISS:UniProtKB
  • positive regulation of lipid storage : ISS:UniProtKB
  • positive regulation of phagocytosis : ISO:RGD
  • positive regulation of phagocytosis, engulfment : ISO:RGD
  • positive regulation of protein phosphorylation : ISS:UniProtKB
  • positive regulation of receptor-mediated endocytosis : ISO:RGD
  • positive regulation of type IIa hypersensitivity : ISO:RGD
  • positive regulation of vascular endothelial growth factor production : ISO:RGD
  • regulation of triglyceride biosynthetic process : ISS:UniProtKB
  • response to bacterium : ISO:RGD
  • response to estradiol : IEP:RGD
  • response to estrogen : IEP:RGD
  • response to glucocorticoid : IEP:RGD
  • response to magnesium ion : IEP:RGD
  • response to progesterone : IEP:RGD
  • tolerance induction : IEP:RGD
  • vertebrate eye-specific patterning : ISO:RGD
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.