| Signal peptide(a) |
Y |
Secretome P(b) |
0.756 |
| Function |
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.Angiotensin-3: stimulates aldosterone release.Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. . |
| GO - Molecular function |
- growth factor activity : TAS:BHF-UCL
- hormone activity : ISS:BHF-UCL
- receptor ligand activity : IDA:BHF-UCL
- serine-type endopeptidase inhibitor activity : TAS:ProtInc
- sodium channel regulator activity : IMP:BHF-UCL
- superoxide-generating NADPH oxidase activator activity : TAS:BHF-UCL
- type 1 angiotensin receptor binding : IPI:BHF-UCL
- type 2 angiotensin receptor binding : IPI:BHF-UCL
|
| GO - Biological process |
- activation of phospholipase C activity : IEA:Ensembl
- aging : IEA:Ensembl
- angiotensin-activated signaling pathway : IDA:BHF-UCL
- angiotensin-mediated drinking behavior : IEA:Ensembl
- artery smooth muscle contraction : IEA:Ensembl
- associative learning : IEA:Ensembl
- blood vessel remodeling : TAS:BHF-UCL
- cell growth involved in cardiac muscle cell development : IEA:Ensembl
- cell surface receptor signaling pathway : IEA:Ensembl
- cell-cell signaling : TAS:ProtInc
- cellular response to angiotensin : IEA:Ensembl
- cellular response to mechanical stimulus : IEA:Ensembl
- cellular sodium ion homeostasis : IEA:Ensembl
- cytokine secretion : IEA:Ensembl
- ERK1 and ERK2 cascade : IEA:Ensembl
- female pregnancy : IEA:Ensembl
- fibroblast proliferation : IEA:Ensembl
- G-protein coupled receptor signaling pathway : IDA:BHF-UCL
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger : TAS:BHF-UCL
- kidney development : IMP:BHF-UCL
- low-density lipoprotein particle remodeling : NAS:BHF-UCL
- negative regulation of angiogenesis : IEA:Ensembl
- negative regulation of cell growth : IEA:Ensembl
- negative regulation of gene expression : IDA:BHF-UCL
- negative regulation of neurotrophin TRK receptor signaling pathway : IDA:BHF-UCL
- negative regulation of sodium ion transmembrane transporter activity : TAS:BHF-UCL
- negative regulation of tissue remodeling : IEA:Ensembl
- nitric oxide mediated signal transduction : TAS:BHF-UCL
- operant conditioning : IEA:Ensembl
- phospholipase C-activating G-protein coupled receptor signaling pathway : NAS:BHF-UCL
- positive regulation of activation of Janus kinase activity : IMP:UniProtKB
- positive regulation of blood pressure : IEA:Ensembl
- positive regulation of branching involved in ureteric bud morphogenesis : IDA:UniProtKB
- positive regulation of cardiac muscle cell apoptotic process : IEA:Ensembl
- positive regulation of cardiac muscle hypertrophy : ISS:BHF-UCL
- positive regulation of cellular protein metabolic process : IDA:BHF-UCL
- positive regulation of cholesterol esterification : IDA:BHF-UCL
- positive regulation of cytokine production : TAS:BHF-UCL
- positive regulation of cytosolic calcium ion concentration : IEA:Ensembl
- positive regulation of endothelial cell migration : IDA:BHF-UCL
- positive regulation of epidermal growth factor receptor signaling pathway : IDA:BHF-UCL
- positive regulation of extracellular matrix constituent secretion : IEA:Ensembl
- positive regulation of extrinsic apoptotic signaling pathway : IDA:BHF-UCL
- positive regulation of fibroblast proliferation : ISS:BHF-UCL
- positive regulation of gap junction assembly : IGI:BHF-UCL
- positive regulation of glucose import in response to insulin stimulus : IEA:Ensembl
- positive regulation of inflammatory response : TAS:BHF-UCL
- positive regulation of L-arginine import across plasma membrane : IEA:Ensembl
- positive regulation of L-lysine import across plasma membrane : IEA:Ensembl
- positive regulation of macrophage derived foam cell differentiation : IC:BHF-UCL
- positive regulation of membrane hyperpolarization : IMP:BHF-UCL
- positive regulation of NAD(P)H oxidase activity : TAS:BHF-UCL
- positive regulation of neuron projection development : IEA:Ensembl
- positive regulation of NF-kappaB transcription factor activity : TAS:BHF-UCL
- positive regulation of nitric oxide biosynthetic process : IEA:Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling : IDA:BHF-UCL
- positive regulation of protein tyrosine kinase activity : IMP:UniProtKB
- positive regulation of reactive oxygen species metabolic process : TAS:BHF-UCL
- positive regulation of renal sodium excretion : IEA:Ensembl
- positive regulation of superoxide anion generation : IEA:Ensembl
- positive regulation of transcription, DNA-templated : IDA:BHF-UCL
- positive regulation of vascular associated smooth muscle cell migration : IEA:Ensembl
- positive regulation of vascular smooth muscle cell proliferation : IEA:Ensembl
- protein import into nucleus : IEA:Ensembl
- regulation of blood pressure : IGI:BHF-UCL
- regulation of blood vessel diameter by renin-angiotensin : TAS:BHF-UCL
- regulation of blood volume by renin-angiotensin : NAS:BHF-UCL
- regulation of calcium ion transport : IEA:Ensembl
- regulation of cardiac conduction : IGI:BHF-UCL
- regulation of cell growth : NAS:BHF-UCL
- regulation of cell proliferation : NAS:BHF-UCL
- regulation of extracellular matrix assembly : IGI:BHF-UCL
- regulation of heart rate : IEA:Ensembl
- regulation of lipid metabolic process : TAS:Reactome
- regulation of long-term neuronal synaptic plasticity : IEA:Ensembl
- regulation of norepinephrine secretion : IEA:Ensembl
- regulation of renal output by angiotensin : NAS:BHF-UCL
- regulation of renal sodium excretion : NAS:BHF-UCL
- regulation of transmission of nerve impulse : IEA:Ensembl
- regulation of vasoconstriction : NAS:BHF-UCL
- renal system process : IDA:UniProtKB
- renin-angiotensin regulation of aldosterone production : NAS:BHF-UCL
- response to estradiol : IEA:Ensembl
- response to muscle activity involved in regulation of muscle adaptation : ISS:BHF-UCL
- smooth muscle cell proliferation : IEA:Ensembl
- stress-activated MAPK cascade : IEA:Ensembl
- uterine smooth muscle contraction : IEA:Ensembl
- vasodilation : IEA:Ensembl
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