Antithrombin-III (P01008)

Uniprot ID P01008
Protein Name Antithrombin-III
Gene Name SERPINC1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.656
Function Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. .
GO - Molecular function
  • heparin binding : IEA:UniProtKB-KW
  • identical protein binding : IPI:IntAct
  • protease binding : IPI:UniProtKB
  • serine-type endopeptidase inhibitor activity : IBA:GO_Central
GO - Biological process
  • acute inflammatory response to antigenic stimulus : IEA:Ensembl
  • blood coagulation : TAS:Reactome
  • cellular protein metabolic process : TAS:Reactome
  • lactation : IEA:Ensembl
  • negative regulation of endopeptidase activity : IBA:GO_Central
  • post-translational protein modification : TAS:Reactome
  • regulation of blood coagulation, intrinsic pathway : IEA:InterPro
  • response to nutrient : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.