Signal peptide(a) |
N |
Secretome P(b) |
0.656 |
Function |
Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. . |
GO - Molecular function |
- heparin binding : IEA:UniProtKB-KW
- identical protein binding : IPI:IntAct
- protease binding : IPI:UniProtKB
- serine-type endopeptidase inhibitor activity : IBA:GO_Central
|
GO - Biological process |
- acute inflammatory response to antigenic stimulus : IEA:Ensembl
- blood coagulation : TAS:Reactome
- cellular protein metabolic process : TAS:Reactome
- lactation : IEA:Ensembl
- negative regulation of endopeptidase activity : IBA:GO_Central
- post-translational protein modification : TAS:Reactome
- regulation of blood coagulation, intrinsic pathway : IEA:InterPro
- response to nutrient : IEA:Ensembl
|