Signal peptide(a) |
N |
Secretome P(b) |
0.646 |
Function |
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). . |
GO - Molecular function |
- adenosine deaminase activity : IDA:UniProtKB
- purine nucleoside binding : IEA:Ensembl
- zinc ion binding : IMP:UniProtKB
|
GO - Biological process |
- adenosine catabolic process : IDA:UniProtKB
- aging : IEA:Ensembl
- cell adhesion : IEA:UniProtKB-KW
- dATP catabolic process : IEA:Ensembl
- deoxyadenosine catabolic process : IEA:Ensembl
- embryonic digestive tract development : IEA:Ensembl
- germinal center B cell differentiation : IEA:Ensembl
- histamine secretion : IEA:Ensembl
- hypoxanthine salvage : IBA:GO_Central
- inosine biosynthetic process : IDA:MGI
- liver development : IEA:Ensembl
- lung alveolus development : IEA:Ensembl
- negative regulation of adenosine receptor signaling pathway : IDA:UniProtKB
- negative regulation of circadian sleep/wake cycle, non-REM sleep : IEA:Ensembl
- negative regulation of inflammatory response : IEA:Ensembl
- negative regulation of leukocyte migration : IEA:Ensembl
- negative regulation of mature B cell apoptotic process : IEA:Ensembl
- negative regulation of mucus secretion : IEA:Ensembl
- negative regulation of penile erection : IEA:Ensembl
- negative regulation of thymocyte apoptotic process : IEA:Ensembl
- Peyer's patch development : IEA:Ensembl
- placenta development : IEA:Ensembl
- positive regulation of alpha-beta T cell differentiation : IEA:Ensembl
- positive regulation of B cell proliferation : IEA:Ensembl
- positive regulation of calcium-mediated signaling : IEA:Ensembl
- positive regulation of germinal center formation : IEA:Ensembl
- positive regulation of heart rate : IEA:Ensembl
- positive regulation of smooth muscle contraction : IEA:Ensembl
- positive regulation of T cell differentiation in thymus : IEA:Ensembl
- positive regulation of T cell receptor signaling pathway : IEA:Ensembl
- purine nucleotide salvage : IMP:UniProtKB
- purine ribonucleoside monophosphate biosynthetic process : IEA:InterPro
- purine-containing compound salvage : TAS:Reactome
- regulation of cell-cell adhesion mediated by integrin : IDA:UniProtKB
- response to hydrogen peroxide : IEA:Ensembl
- response to hypoxia : IDA:UniProtKB
- response to morphine : IEA:Ensembl
- response to vitamin E : IEA:Ensembl
- T cell activation : IDA:UniProtKB
- trophectodermal cell differentiation : IEA:Ensembl
- xanthine biosynthetic process : IEA:Ensembl
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