Adenosine deaminase (P00813)

Uniprot ID P00813
Protein Name Adenosine deaminase
Gene Name ADA
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.646
Function Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). .
GO - Molecular function
  • adenosine deaminase activity : IDA:UniProtKB
  • purine nucleoside binding : IEA:Ensembl
  • zinc ion binding : IMP:UniProtKB
GO - Biological process
  • adenosine catabolic process : IDA:UniProtKB
  • aging : IEA:Ensembl
  • cell adhesion : IEA:UniProtKB-KW
  • dATP catabolic process : IEA:Ensembl
  • deoxyadenosine catabolic process : IEA:Ensembl
  • embryonic digestive tract development : IEA:Ensembl
  • germinal center B cell differentiation : IEA:Ensembl
  • histamine secretion : IEA:Ensembl
  • hypoxanthine salvage : IBA:GO_Central
  • inosine biosynthetic process : IDA:MGI
  • liver development : IEA:Ensembl
  • lung alveolus development : IEA:Ensembl
  • negative regulation of adenosine receptor signaling pathway : IDA:UniProtKB
  • negative regulation of circadian sleep/wake cycle, non-REM sleep : IEA:Ensembl
  • negative regulation of inflammatory response : IEA:Ensembl
  • negative regulation of leukocyte migration : IEA:Ensembl
  • negative regulation of mature B cell apoptotic process : IEA:Ensembl
  • negative regulation of mucus secretion : IEA:Ensembl
  • negative regulation of penile erection : IEA:Ensembl
  • negative regulation of thymocyte apoptotic process : IEA:Ensembl
  • Peyer's patch development : IEA:Ensembl
  • placenta development : IEA:Ensembl
  • positive regulation of alpha-beta T cell differentiation : IEA:Ensembl
  • positive regulation of B cell proliferation : IEA:Ensembl
  • positive regulation of calcium-mediated signaling : IEA:Ensembl
  • positive regulation of germinal center formation : IEA:Ensembl
  • positive regulation of heart rate : IEA:Ensembl
  • positive regulation of smooth muscle contraction : IEA:Ensembl
  • positive regulation of T cell differentiation in thymus : IEA:Ensembl
  • positive regulation of T cell receptor signaling pathway : IEA:Ensembl
  • purine nucleotide salvage : IMP:UniProtKB
  • purine ribonucleoside monophosphate biosynthetic process : IEA:InterPro
  • purine-containing compound salvage : TAS:Reactome
  • regulation of cell-cell adhesion mediated by integrin : IDA:UniProtKB
  • response to hydrogen peroxide : IEA:Ensembl
  • response to hypoxia : IDA:UniProtKB
  • response to morphine : IEA:Ensembl
  • response to vitamin E : IEA:Ensembl
  • T cell activation : IDA:UniProtKB
  • trophectodermal cell differentiation : IEA:Ensembl
  • xanthine biosynthetic process : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.