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P00786

Pro-cathepsin H (P00786)

Uniprot ID P00786
Protein Name Pro-cathepsin H
Gene Name Ctsh
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Important for the overall degradation of proteins in lysosomes.
GO - Molecular function
  • aminopeptidase activity : IDA:RGD
  • cysteine-type endopeptidase activator activity involved in apoptotic process : ISS:UniProtKB
  • cysteine-type endopeptidase activity : ISS:UniProtKB
  • cysteine-type peptidase activity : ISO:RGD
  • endopeptidase activity : ISO:RGD
  • HLA-A specific activating MHC class I receptor activity : ISS:UniProtKB
  • kininogen binding : IPI:RGD
  • peptidase activator activity involved in apoptotic process : ISO:RGD
  • peptidase activity : ISO:RGD
  • protein self-association : IDA:RGD
  • protein-containing complex binding : IPI:RGD
  • serine-type endopeptidase activity : ISS:UniProtKB
  • thyroid hormone binding : ISS:UniProtKB
GO - Biological process
  • adaptive immune response : ISO:RGD
  • bradykinin catabolic process : ISS:UniProtKB
  • cellular response to thyroid hormone stimulus : IEP:UniProtKB
  • dichotomous subdivision of terminal units involved in lung branching : ISS:UniProtKB
  • ERK1 and ERK2 cascade : ISS:UniProtKB
  • immune response-regulating signaling pathway : ISS:UniProtKB
  • membrane protein proteolysis : ISS:UniProtKB
  • metanephros development : IEP:UniProtKB
  • negative regulation of apoptotic process : ISS:UniProtKB
  • neuropeptide catabolic process : ISS:UniProtKB
  • positive regulation of angiogenesis : ISS:UniProtKB
  • positive regulation of apoptotic signaling pathway : ISO:RGD
  • positive regulation of cell migration : ISS:UniProtKB
  • positive regulation of cell population proliferation : ISS:UniProtKB
  • positive regulation of epithelial cell migration : ISS:UniProtKB
  • positive regulation of gene expression : ISS:UniProtKB
  • positive regulation of peptidase activity : ISS:UniProtKB
  • protein destabilization : ISS:UniProtKB
  • proteolysis : IEP:RGD
  • proteolysis involved in cellular protein catabolic process : IBA:GO_Central
  • response to odorant : IEP:RGD
  • response to retinoic acid : ISS:UniProtKB
  • spermatogenesis : IEP:RGD
  • surfactant homeostasis : ISS:UniProtKB
  • T cell mediated cytotoxicity : ISS:UniProtKB
  • zymogen activation : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.