Tissue-type plasminogen activator (P00750)

Uniprot ID P00750
Protein Name Tissue-type plasminogen activator
Gene Name PLAT
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b) 0.638
Function Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
GO - Molecular function
  • phosphoprotein binding : IPI:AgBase
  • serine-type endopeptidase activity : IDA:BHF-UCL
  • signaling receptor binding : IPI:AgBase
GO - Biological process
  • blood coagulation : TAS:ProtInc
  • cellular protein modification process : TAS:ProtInc
  • fibrinolysis : TAS:Reactome
  • negative regulation of proteolysis : IDA:BHF-UCL
  • plasminogen activation : IDA:UniProtKB
  • platelet-derived growth factor receptor signaling pathway : IEA:Ensembl
  • proteolysis : TAS:ProtInc
  • response to hypoxia : IEA:Ensembl
  • smooth muscle cell migration : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.