| Signal peptide(a) |
N |
Secretome P(b) |
0.847 |
| Function |
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). . |
| GO - Molecular function |
- guanine phosphoribosyltransferase activity : ISS:UniProtKB
- hypoxanthine phosphoribosyltransferase activity : IDA:MGI
- identical protein binding : IPI:MGI
- magnesium ion binding : ISO:MGI
- nucleotide binding : IEA:UniProtKB-KW
- protein homodimerization activity : ISO:MGI
|
| GO - Biological process |
- adenine metabolic process : IMP:MGI
- adenine salvage : IMP:MGI
- central nervous system neuron development : IMP:MGI
- cerebral cortex neuron differentiation : IMP:MGI
- cytolysis : IMP:MGI
- dendrite morphogenesis : IMP:MGI
- dopamine metabolic process : IMP:MGI
- GMP catabolic process : ISS:UniProtKB
- grooming behavior : IGI:MGI
- guanine salvage : IMP:MGI
- hypoxanthine metabolic process : IMP:MGI
- hypoxanthine salvage : ISS:UniProtKB
- IMP metabolic process : ISS:UniProtKB
- IMP salvage : IEA:UniProtKB-UniPathway
- locomotory behavior : IMP:MGI
- lymphocyte proliferation : IMP:MGI
- positive regulation of dopamine metabolic process : IMP:MGI
- protein homotetramerization : ISO:MGI
- purine nucleotide biosynthetic process : ISO:MGI
- purine ribonucleoside salvage : IMP:MGI
- response to amphetamine : IMP:MGI
- striatum development : IMP:MGI
|